| 24(S)-hydroxy CholesterolLXRα and LXRβ nuclear receptors activator |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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| Cas No. | 474-73-7 | SDF | Download SDF |
| Synonyms | Cerebrosterol | ||
| Chemical Name | cholest-5-ene-3β,24S-diol | ||
| Canonical SMILES | O[C@@H]1CC2=CC[C@]3([H])[C@@](CC[C@]4([C@@]3([H])CC[C@]4([H])[C@@H](CC[C@H](O)C(C)C)C)C)([H])[C@](C)2CC1 | ||
| Formula | C27H46O2 | M.Wt | 402.7 |
| Solubility | ≤20mg/ml in ethanol;0.1mg/ml in DMSO;2mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
24S-hydroxycholesterol (24S-OH-Chol) is an enzymatically oxidized product of cholesterol mainly synthesized in the brain, involved in the pathogenesis of Alzheimer disease (AD) [1].
24(S)-hydroxy Cholesterol has been generated by the action of enzyme cholesterol 24(S)-hydroxylase (CYP46) on cholesterol in the brain. 24(S)-hydroxy Cholesterol can diffuse across the blood-brain barrier to the systemic circulation where it modulates cell signaling, which could be used for further sterol biosynthesis, or be metabolized in the liver. In brain, disturbances of cholesterol homeostasis have been associated with severe neurological diseases and play a dominant role in the development of Alzheimer disease (AD).
In AD patients, the levels of 24(S)-hydroxycholesterol have been increased in cerebrospinal fluid [1]. 24(S)-hydroxycholesterol is able to induce the expression of ABCA1, ABCG1, and apoE in astrocytes and to elevate apoE-mediated cholesterol efflux in astrocytoma but not in neuroblastoma cells [1]. The concentration of 24(S)-hydroxycholesterol in AD and non-Alzheimer demented patients was modestly but significantly higher than in healthy volunteers and in depressed patients. Plasma 24(S)-hydroxycholesterol levels negatively correlated with the severity of dementia. 24(S)-hydroxycholesterol plasma levels may potentially be used as an early biochemical marker for an altered cholesterol homeostasis in the central nervous system [2]. 24(S)-hydroxycholesterol is a natural ligand of the liver X receptors (LXR), central players in the regulation of cholesterol metabolism. 24(S)-hydroxycholesterol potently activated LXRα and LXRβ nuclear receptors with the EC50 values of 4 and 3 μM, respectively, causing upregulation of cholesterol-lowering genes.
References:[1] Abildayeva K, Jansen P J, Hirsch-Reinshagen V, et al. 24 (S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux[J]. Journal of Biological Chemistry, 2006, 281(18): 12799-12808.[2] Lütjohann D, Papassotiropoulos A, Bjrkhem I, et al. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients[J]. Journal of Lipid Research, 2000, 41(2): 195-198.[3] Janowski, B. A.,Grogan, M.J.,Jones, S.A., et al. Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ. Proceedings of the National Academy of Sciences of the United States of America 96(1), 266-271 (1999).
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密封良好的移液器，只要调节机构经过校准并且可以稳定保持精度，就不必担心有问题。
换算
1微升 = 0.000 000 001立方米
1微升 = 0.000 001 立方分米
1微升 = 0.000 001 升
1微升 = 0.001 毫升
1微升 = 0.001 立方厘米
1微升 = 1 立方毫米
1微升 = 1 000 纳升
（1）移液杆可360旋转,不用工具可卸下121℃高温灭菌。
（2）符合人体工程学的外型设计。
（3）符合ISO9000和GLP规定，用户可独立校准。数字可调式移液器校准不需要工具。同时有较高的精度和误差系数。
（4）吸头接嘴有独特的V形圈，可以适合不同品牌的吸头。
移液器应用范围：
临床诊断实验室，生物技术实验室，药学和化学实验室，环境实验室，食品实验室
所有移液器都可以用酒精或紫外灭菌处理，但要整支灭菌，其他的品牌就相对不占优势了。eppendorf research plus所有移液器都可以整支高温高压灭菌，这个是艾本德移液器的强势地方。
综合考虑在中国大陆地区选择Eppendorf多些，客户分应用反馈也是比较好的。建议购买艾本德移液器！
现在市场上经常把移液器分为三大类：
高端产品：非常精确耐用，Eppendorf、Gilson、RAININ和BIOHIT等品牌；
中端产品：一般精确耐用，BRAND、NICHIRYO(立洋)、SOCOREX、FinnPipette、CAPP和Hamilton等；
低端产品：大龙等等国产品牌，好在便宜，可以经常换。
各大移液器官方旗舰店
Eppendof旗舰店
RAININ旗舰店（METTLER旗下品牌）
BIOHIT旗舰店
大龙专卖店
Finnpipette旗舰店（ThermoFisher旗下品牌）
邀请广大战友来谈论一下使用移液器的心得和选购经验··········
版主鱼小留言:
支持活动。
国产移液器市场占有率高，以物美价廉占据市场。其次国产移液器有北京的金花移液器，整体构造仿造吉尔森移液器。其次就是一些打着国外移液器品牌，其实生产工厂大多在浙江和上海，以完全模仿国外或国产品牌为主。
进口品牌：艾本德、吉尔森移液器一直以来以良好的精准度和重复性被用户所青睐，艾本德新款移液器因为设计结构的问题，容易损坏。吉尔森移液器主要是人体工程学设计有所欠缺，吸液按钮比较硬，长时间使用容易产生疲劳感。
其次品牌：芬兰百得、美国瑞宁、德国普兰德、丹麦凯博、芬兰艾斯玛特、日本立洋等。
进口品牌产品每年都会涨价，特别是艾本德、吉尔森等一类品牌。现在移液器参数标准进口产品都没问题，贵在品牌和客户的青睐度。芬兰百得、美国瑞宁、德国普兰德也在向一类品牌移液器发展，价格直追一类品牌。
性价比高的进口品牌：
丹麦凯博、芬兰艾斯玛特、日本立洋等
