
Product Description
Recombinant 2019-nCoV Nucleocapsid Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala419 is expressed with a 6His tag at the N-terminus.Background:Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. N protein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.Formulation:Supplied as a 0.2 μM filtered solution of 20 mM Tris-HCl, 300 mM NaCl, 1mM EDTA, pH 8.0.Purity:> 95 % as determined by reducing SDS-PAGE.Endotoxin:< 1.0 EU per µg as determined by the LAL method.Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C. Avoid freeze-thaw cycles.
More Details:Sequence:Met1-Ala419Fusion Tag:N-6HisAccession:QHD43423.2Species:VirusExpression System:E. coliMol Mass:49.4 kDaAP Mol Mass:50-60 kDaSynonyms:2019-nCoV coronavirus NP Protein; 2019-nCoV np Protein; 2019-nCoV novel coronavirus Nucleoprotein ProteinDatasheet
FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.Manufactured by: Elabscience
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第三道防线是人体在出生以后逐渐建立起来的后天防御功能,特点是出生后才产生的,只针对某一特定的病原体或异物起作用,因而叫做特异性免疫(又称后天性免疫)。后天性免疫--免疫的第三道防线免疫的第三道防线:特异性免疫。主要由免疫细胞--淋巴B、淋巴T细胞进行免疫。其中,淋巴B细胞“负责”体液免疫;淋巴T细胞“负责”细胞免疫。后天性的特异性免疫系统,是一个专一性的免疫机制,针对一种抗原所生成的免疫淋巴细胞分泌的抗体,只能对同一种抗原发挥免疫功能。而对变异或其他抗原毫无作用。第1、2防线,就好比杀毒软件本体;第3到防线就好比病毒/木马专杀软件。只有3道防线同时、完整、完好发挥免疫作用,我们的身体健康才能更充分的得到保证。展开
抗原:
(antigen,缩写Ag)为任何可诱发免疫反应的物质。外来分子可经过B细胞上免疫球蛋白的辨识或经抗原呈现细胞的处理并与主要组织相容性复合体结合成复合物再活化T细胞,引发连续的免疫反应。
抗体:
(英语:antibody),(免疫球蛋白不仅仅只是抗体)是一种由浆细胞(效应B细胞)分泌,被免疫系统用来鉴别与中和外来物质如细菌、病毒等的大型Y形蛋白质,仅被发现存在于脊椎动物的血液等体液中,及其B细胞的细胞膜表面[1-2]。抗体能识别特定外来物的一个独特特征,该外来目标被称为抗原。
抗原抗体反应:
指抗原与相应抗体之间所发生的特异性结合反应。这种反应既可在机体内进行,也可以在机体外进行。抗原抗体反应的过程是经过一系列的化学和物理变化,包括抗原抗体特异性结合和非特异性促凝聚两个阶段,以及由亲水胶体转为疏水胶体的变化。
由此,注射疫苗(没有破坏力但却能刺激机体产生对应的抗体)属于主动免疫,注射血清(即抗体)属于被动免疫,前者旨在预防,标本兼治,后者则能够应急。

