Recombinant Human Ataxin UIM Domains Biotin Protein, CF Summary
The Ubiquitin-interacting Motif (UIM) is an alpha-helical Ubiquitin-binding domain found in many proteins that recognizes and traffics ubiquitinated cargo (1,2). Ataxin-3, a deubiquitinating enzyme that contains three consecutive UIM motifs (amino acids (aa) 224-243, 244-263, 331-348), functions as a mixed lineage, chain editing enzyme that recognizes and binds K48-linked and K63-linked poly-Ubiquitin chains (3-5). The UIM domain of Ataxin-3 (aa 224-348) preferentially interacts with four or more Ubiquitin units of K48-linked or K63-linked poly-Ubiquitin chains or ubiquitinated substrates that contain these linkages (4,6,7).
This protein can be used for the isolation and identification of K48-linked (preferentially) or K63-linked poly-Ubiquitin chains or ubiquitinated substrates that contain these linkages. Detection with avidin-linked reagents allows for a higher efficiency and detection sensitivity than with other antibodies.
Specifications
- 12 months from date of receipt, -70 °C as supplied.
- 3 months, -70 °C under sterile conditions after opening.
Product Datasheets
Background: Ataxin UIM Domains
Reagents Provided
FAQs
No product specific FAQs exist for this product, however you may
View all Proteins and Enzyme FAQsAffinity Matrices
Recombinant Human HR23A Tandem UBA (TUBE1) Agarose, CF
Recombinant Enzymes
Recombinant Human Parkin W403A Protein, CF
Recombinant Human Ataxin-3 Like Protein, CF
Recombinant Proteins
Recombinant Human p53 Protein, CF
Staining Reagents
NorthernLights Streptavidin NL557
Streptavidin-Alkaline Phosphatase
Avidin-Fluorescein
Streptavidin-Phycoerythrin
NorthernLights Streptavidin NL637
Streptavidin-Allophycocyanin
NorthernLights Streptavidin NL493
Supplemental Cell Selection Products
MagCellect Streptavidin Ferrofluid
Supplemental ELISA Products
Streptavidin-HRP
EvenCoat Streptavidin Coated Plates, 5 Pack
EvenCoat Streptavidin Coated Plates
Reviews for Recombinant Human Ataxin UIM Domains Biotin Protein, CF
There are currently no reviews for this product. Be the first toreview Recombinant Human Ataxin UIM Domains Biotin Protein, CF and earn rewards!
Have you used Recombinant Human Ataxin UIM Domains Biotin Protein, CF?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
>
