- Exemestane
- Aminoglutethimide
- Formestane
- Anastrozole
| LetrozoleNon-steroidal aromatase inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
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- Purity = 99.90%
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Chemical structure
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| Cas No. | 112809-51-5 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile | ||
| Canonical SMILES | C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3 | ||
| Formula | C17H11N5 | M.Wt | 285.3 |
| Solubility | ≥14.265mg/mL in DMSO | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Letrozole is a novel and potent type (II) aromatase inhibitor with IC50 of 11.5 nM. It belongs to the reversible non-steroidal compound family which can inhibit Arom. However, there is no evidence that it can affect the adrenal steroidogenesis.[1]
Normally, Type II inhibitors have a common feature of heterocyclic azole moiety, which can be binded to the heme–iron in aromatase. It contains a structure of 1,2,4-triazole moieties which can coordinate the heme–iron of cytochrome P450. Meanwhile, benzonitrile substituted letrozole can mimic a unique enzyme structure of the substrate androstenedione.[2]
Letrozole administration can reduce spine synapse and axon outgrowth and it also will decrease the expression of estrogen receptor (ER). While, the synaptic proteins including GAP-43 can impaire the long-termpotentiation.[1] Letrozole is proved to promote FSH release from the hypothalamic pituitary axis by responding to decreased estrogen (E) feedback.[3]
References:[1] Chen Bian, Yangang Zhao, Qiang Guo, Ying Xiong, Wenqin Cai, Jiqiang Zhang. Aromatase inhibitor letrozole downregulates steroid receptor coactivator-1 in specific brain regions that primarily related to memory, neuroendocrine and integration. The Journal of Steroid Biochemistry and Molecular Biology. May 2014. 141: 37-43.[2] Hakki Türker Akçay, Riza Bayrak. Computational studies on the anastrozole and letrozole, effective chemotherapy drugs against breast cancer. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 25 March 2014. 122: 142-152.[3] Lindsay Malloch, Alice Rhoton-Vlasak. An assessment of current clinical attitudes toward letrozole use in reproductive endocrinology practices. Fertility and Sterility. December 2013. 100(6): 1740-1744.
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要做细胞缺氧，需要买细胞缺氧盒，但不知道哪里有卖，各位大神有没有曾经做过的，能不能告诉我在哪能购买到，哪个公司有卖。。急。。。。。。实验小白。。。。在下先在此谢过了。
小弟现有一事儿想求助！
如下：1）凋亡的时候细胞色素c由线粒体里释放到胞浆里去的。那么如果能够测到此时在胞浆里的细胞色素c表达增多的话应该就能说明问题了
（2）可此时的问题是如果提胞浆蛋白时把线粒体也裂解了话细胞色素c也会被释放出来，还是会在胞浆里大量表达！就说不清楚是凋亡由线粒体释放的还是被人为的破坏了线粒体导致了的！！！
（3）故我的问题就是该怎么样去除这个人为的影响？怎么说明我测的胞浆里的细胞色素c就是凋亡时线粒体释放的？换句话讲就是如果能够在用细胞裂解液裂解胞浆蛋白时，将线粒体剔除掉？
是不是买个细胞色素c的测试盒就可以了啊？这个盒子有人用过吗，请指教一二！
盼复！非常感谢！
以前先放-80再液氮，但是去-80冰箱有点远，我想能不能直接放液氮里面，我直接放过复苏成活率低了很多，有没有这种冻存盒可以直接放液氮的？
心肌肌钙蛋白I，英文为CardiactroponinI，该试剂盒在POCT领域内几乎是每个厂家都必做的项目，也是多数医院科室都开展的收费项目，市场容量很大，全国一年下来保守估计有3千万人份。但有些厂家销售的特别好，有些厂家销售的很一般。这一是由于销售渠道所致、二是因为产品质量差导致。试剂盒质量差一是因为厂家自身调试工艺不太好，二是由于所选择的抗体质量不好所致。现在市面上有心肌肌钙蛋白I抗体的厂家不多，大概也就不超过10家吧，主要为进口品牌，如：HyTest、BBI、Biospacific、Medix，国产品牌为深圳菲鹏，杭州启泰。其中着重要说的是杭州启泰，这是一家成立7年的抗原、抗体研发公司，公司不大，但立足于自主研发、创新，最近新推出的cTnI抗体可以说是目前国内外最好的抗体，这也算是填补了国内该领域的空白。从事了该行业将近10年，发此贴也是真切希望国内的生物试剂类公司，都专注于研发、创新，做一些好的试剂出来。因为很多事情国内做的并不比国外差的，国内的生物同行请加油吧!
