Product Name | Pannexin - 1 (Panx1), Mimetic Blocking PeptideWRQAAFVDSY |
Size | 1 mg |
Catalog # | AS-61911 |
US$ | $73 |
Purity | % Peak Area By HPLC ≥ 95% |
This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1? (IL-1?) in response to P2X7R activation. | |
Detailed Information | DatasheetMaterial Safety Data Sheets (MSDS) |
Storage | -20°C |
References | Pelegrin, P. et al. EMBO.J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007). |
Molecular Weight | 1242.4 |
WRQAAFVDSY | |
Sequence(Three-Letter Code) | H - Trp - Arg - Gln - Ala - Ala - Phe - Val - Asp - Ser - Tyr - OH |
Product Citations | Karpuk, N. et al. (2011). Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity. J Neurosci 31, 414. |
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