
Product Name | Glucagon - Like Peptide 1, GLP - 1 (7 - 36), amide, humanHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR - NH2 |
Size | 1 mg |
Catalog # | AS-22463 |
US$ | $238 |
Purity | % Peak Area By HPLC ≥ 95% |
GLP-1 (7-36) amide is an incretin hormone that causes glucose dependent release of insulin by pancreaticbeta cells.It is the cleavage product of GLP-1 (1-36) amide peptide (Cat# AS-22460).Both GLP-1 (7-36) andGLP-1 (7-37)-Cat# AS-20761, also play roles in gastric motility (gastric emptying), on the suppression of plasma glucagon levels (glucose production) and possibly on the promotion of satiety and stimulation of glucose disposal in peripheral tissues independent of the actions of insulin.GLP-1 (7-36) has a short half life of less than 2 minutes, and like GIP, is rapidly degraded by the enzyme dipeptidyl peptidase IV (DPP-4),which is widely expressed in a number of sites, including the endothelial cells of small gut arterioles.DPP-4 degrades GLP-1 (7-36) into the non insulinotropic GLP-1 (9-36)-Cat# AS-65070 (some studies suggest it may have weak insulinotropic activity). As a result, the majority of GLP-1 (and GIP) is inactivated as an insulinotrope before reaching the systemic circulation. | |
Detailed Information | ![]() ![]() |
Storage | -20°C |
References | Drucker, D. et al. Proc Natl Acad Sci USA 84, 3434 (1987) Kieffer, T. and J. Habener, Endo Rev 20, 876 (1999)Deacon, CF. et. al. Hormone Metabolic Res 36,761 (2004), doi: 10.1055/s-2004-826160Williams, JA. Pancreadepedia (2014), doi: 10.3998/panc.2014.7Elahi, D. et. al. Obesity (Silver Spring) 16, 1501 (2008), doi: 10.1038/oby.2008.229Ban, K. et. al. Endocrinol 151, 1520 (2010), doi: http://dx.doi.org/10.1210/en.2009-1197 |
Molecular Weight | 3297.7 |
HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2 | |
Sequence(Three-Letter Code) | H - His - Ala - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Val - Ser - Ser - Tyr - Leu - Glu - Gly - Gln - Ala - Ala - Lys - Glu - Phe - Ile - Ala - Trp - Leu - Val - Lys - Gly - Arg - NH2 |
Product Citations | Tashiro Y et al. (2014) A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis; Peptides 54, 19-26. Puddu A et al. (2010) Glucagon-like peptide-1 counteracts the detrimental effects of Advanced Glycation End-Products in the pancreatic beta cell line HIT-T 15. Biochem Biophys Res Commun 398, 462. |
ebiomall.com






>
>
>
>
>
>
>
>
>
>
>
>
间歇式高剪切分散乳化均质机是通过转子高速平稳的旋转,形成高频、强烈的圆周切线速度、角向速度等综合动能效能;在定子的作用下,定、转子合理狭窄的间隙中形成强烈、往复的液力剪切、摩擦、离心挤压、液流碰撞等综合效应,物料在容器中循环往复以上工作过程,最终获得产品。向左转|向右转

