
Immunogen: Activated human NK cells
Isotype: Murine IgG2b
Human CD161 is a homodimeric disulfide-linked type II membrane bound glycoprotein found mainly on NK cells. CD161 has been implicated in the regulation of NK cell mediated cytotoxicity. CD161 positive TH17 cells are resistant to Treg mediated suppression.(5).
Antibody B199.2 recognizes the dimeric 160 kd CD161 molecule.
Functional Application: In MLR, blockade with antibody B199.2 caused a slight but significant reduction in the percentage of IFN gamma-expressing NK cells challenged with M. tuberculosis (4).
References:
1) I.M. Bennett, et al, (1996) J Exp Med 184: 1845-1856.
2)L. Azzoni, et al, (1998) J Immunol 161: 3493-3500.
3) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 307-317.
4) Schierloh P, MC Sasiain, et al. (2007) Infection and Immunity 75(11): 5325-5337.
5) S A Basdeo, J M Fletcher, et al. (2015) J Immunol 195(2): 528-540. PMID 26062995.
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刚对实验室的通风柜做了个气流流向测试,报告出来了不知道该怎么管理这个文件了,当做设备确认方案?感觉不是很合理。放公司的安环部门?他们也没有档案室。我该怎么保存这个文件呢?
无管道型:内置高效活性碳过滤器,可直接排放到室内。
补风型:从室外补充空气,减轻实验室空调的负荷。
连体型:扩大实验空间,为大型仪器提供方便。
桌上型:装在实验台上的通风柜
两面型:从两面可以操作
落地型:适用于大型实验装置向左转|向右转

