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QuantideX® NGS RNA Lung Cancer Kit

rna-lung-cancer-kit-box-photo-for-webThe QuantideX® NGS RNA Lung Cancer Kit* is a clinical research tool enabling the simultaneous assessment of fusions, exon skipping, and other expression targets frequently observed in non-small cell lung cancer (NSCLC). Leveraging our proprietary NGS-in-a-Box™ workflow and Sample-Aware™ bioinformatics quality control solutions, this kit offers a simple, sensitive, and reliable NGS assay for routine investigation of NSCLC samples.

Features & Benefits

The QuantideX NGS RNA Lung Cancer Kit offers a unique NGS-in-a-Box™ solution that provides unprecedented NGS workflow efficiency and high sensitivity at low input amounts from precious FFPE NSCLC samples.

Reduced ComplexityAssay incorporates sample-to-data solutions in a unique NGS-in-a-Box™ configuration

  • Single assay for a broad range of important NSCLC fusion targets
  • All-inclusive reagents from reverse transcription to NGS-ready library
  • Fully integrated data analysis pipeline

Optimized WorkflowEfficient workflow leads to lower operational costs and reduced hands-on and total turnaround time*

  • Reduced labor vs. current commercially available kits
  • Improved turnaround time enables higher throughput

*Internal data on file.

Quality PerformanceHighly sensitive assay with integrated, Sample-Aware™ bioinformatics software and built-in quality checks to minimize erroneous results and sample failures

  • Highly sensitive detection of RNA-based fusions
  • Low input (~20ng) of RNA from FFPE
  • Sample-Aware™ bioinformatics analysis and sample quality control

Download Brochure

*For Research Use Only. Not for use in Diagnostic procedures.

Product Description

Relevant ContentA focus on only the most important lung cancer fusion genes, MET exon 14 skipping events, 3’/5′ imbalances and mRNA expression from multiple published data sources such as COSMIC, ClinicalTrials.gov, NCCN Guidelines, etc.

  • 107 NSCLC-relevant fusions
  • ALK, RET, ROS1, and NTRK1 3’/5’ imbalances
  • MET exon 14 skipping events (e13/e14; e14/e15; e13/e15)
  • 23 mRNA targets, plus 3 endogenous control transcripts

A Fully Integrated WorkflowA unique NGS-in-a-Box™ configuration offers a simplified and fully integrated NGS workflow with cGMP-manufactured reagents, components and controls ready to run right out of the box.

Includes:

  • RT-PCR reagents
  • A unique RNA Lung Cancer Sample QC kit (QuantideX qPCR RNA Assay (Lung))
  • Gene-specific PCR primers and Master Mix reagents
  • Barcodes for sample multiplexing
  • Library purification and quantification reagents
  • Integrated data analysis and reporting software (QuantideX NGS Reporter)

workflow-image-for-web

Rapid & EfficientAdopt and run NGS-based analysis with minimum investment of time and resources, regardless of NGS experience and infrastructure.

  • Fully integrated workflow reduces complexity and ensures reliable reagent quality
  • Push-button analysis & reporting makes bioinformatics easy and efficient, regardless of experience level
  • Integrated kit reduces workflow time by over 50% than competing NGS panels

workflowanalyis_comparew-archer_updated

Performance DataQuantideX NGS Assay is capable of detecting fusions and splice variants down to 1:100 cells. (a) Admixture of MET exon 14 positive cell line in the background of wild-type cells, and (b) fusion, and (c) 3’/5’ imbalance status for an admixture of EML4-ALK positive FFPE in the background of a negative FFPE.

Figure 3a

Figure 3a

Figure 3b

Figure 3c

Figure 3c

*For Research Use Only. Not for use in Diagnostic procedures.

QuantideX® NGS Reporter

Quantidex-Reporter-ComputerPush-button analytics & reporting suite – Set-up-and-go workflow designed for easy installation and implementation, right out of the box.

Runs directly on lab desktop – Install locally on a Windows® desktop computer. No prior bioinformatics experience or large server environments required.

Comprehensive reporting – Full bioinformatics and reporting of variants (SNVs, SNPs, Indels, fusions), and standard QC metrics are automatically calculated.

Integrates QuantideX RNA/DNA QC AssaySample-Aware™ bioinformatics with integrated functional template copy number analysis dramatically reduces false-call rates.

Seamless updates offered with new panel designs & variant annotation – Software updates allow new panels to be adopted without re-investing in analytics when the Asuragen QuantideX NGS product line is adopted.

Contact us to request the QuantideX Reporter

Resources

Videos

Evaluation of an NGS Assay for Detecting RNA Fusions and Splicing Events in Lung Cancer

Next-Generation Sequencing Within Your Reach: Targeted RNA Sequencing to Help Guide NSCLC Patient Care

Posters

Accurate and Reproducible Detection of Fusions and Exon Skipping Events in NSCLC-Derived Samples Using A Comprehensive, Targeted RNA-Seq System Across Multiple LaboratoriesView full poster

Head-To-Head Comparison of Two Commercially Available Next-Generation Sequencing Technologies That Detect Gene Fusions In Non-Small Cell Lung CancerView full poster

A Simple and Versatile Next-Generation Sequencing Technology for Co-Detection of RNA Structural Variants and DNA Mutations in Lung Cancer View full poster

Ordering

Product NameNumber of ReactionsCatalog Number
QuantideX NGS RNA Lung Cancer Kit*4849602
QuantideX NGS RNA Lung Cancer Kit*19249603

T 1-877-777-1874; 512-681-5200 F 512-681-5202 E orders@asuragen.com

View Sales Contacts

*For Research Use Only. Not for use in Diagnostic procedures.

QuantideX® NGS RNA Lung Cancer Kit

rna-lung-cancer-kit-box-photo-for-webThe QuantideX® NGS RNA Lung Cancer Kit* is a clinical research tool enabling the simultaneous assessment of fusions, exon skipping, and other expression targets frequently observed in non-small cell lung cancer (NSCLC). Leveraging our proprietary NGS-in-a-Box™ workflow and Sample-Aware™ bioinformatics quality control solutions, this kit offers a simple, sensitive, and reliable NGS assay for routine investigation of NSCLC samples.

Features & Benefits

The QuantideX NGS RNA Lung Cancer Kit offers a unique NGS-in-a-Box™ solution that provides unprecedented NGS workflow efficiency and high sensitivity at low input amounts from precious FFPE NSCLC samples.

Reduced ComplexityAssay incorporates sample-to-data solutions in a unique NGS-in-a-Box™ configuration

  • Single assay for a broad range of important NSCLC fusion targets
  • All-inclusive reagents from reverse transcription to NGS-ready library
  • Fully integrated data analysis pipeline

Optimized WorkflowEfficient workflow leads to lower operational costs and reduced hands-on and total turnaround time*

  • Reduced labor vs. current commercially available kits
  • Improved turnaround time enables higher throughput

*Internal data on file.

Quality PerformanceHighly sensitive assay with integrated, Sample-Aware™ bioinformatics software and built-in quality checks to minimize erroneous results and sample failures

  • Highly sensitive detection of RNA-based fusions
  • Low input (~20ng) of RNA from FFPE
  • Sample-Aware™ bioinformatics analysis and sample quality control

Download Brochure

*For Research Use Only. Not for use in Diagnostic procedures.

Product Description

Relevant ContentA focus on only the most important lung cancer fusion genes, MET exon 14 skipping events, 3’/5′ imbalances and mRNA expression from multiple published data sources such as COSMIC, ClinicalTrials.gov, NCCN Guidelines, etc.

  • 107 NSCLC-relevant fusions
  • ALK, RET, ROS1, and NTRK1 3’/5’ imbalances
  • MET exon 14 skipping events (e13/e14; e14/e15; e13/e15)
  • 23 mRNA targets, plus 3 endogenous control transcripts

A Fully Integrated WorkflowA unique NGS-in-a-Box™ configuration offers a simplified and fully integrated NGS workflow with cGMP-manufactured reagents, components and controls ready to run right out of the box.

Includes:

  • RT-PCR reagents
  • A unique RNA Lung Cancer Sample QC kit (QuantideX qPCR RNA Assay (Lung))
  • Gene-specific PCR primers and Master Mix reagents
  • Barcodes for sample multiplexing
  • Library purification and quantification reagents
  • Integrated data analysis and reporting software (QuantideX NGS Reporter)

workflow-image-for-web

Rapid & EfficientAdopt and run NGS-based analysis with minimum investment of time and resources, regardless of NGS experience and infrastructure.

  • Fully integrated workflow reduces complexity and ensures reliable reagent quality
  • Push-button analysis & reporting makes bioinformatics easy and efficient, regardless of experience level
  • Integrated kit reduces workflow time by over 50% than competing NGS panels

workflowanalyis_comparew-archer_updated

Performance DataQuantideX NGS Assay is capable of detecting fusions and splice variants down to 1:100 cells. (a) Admixture of MET exon 14 positive cell line in the background of wild-type cells, and (b) fusion, and (c) 3’/5’ imbalance status for an admixture of EML4-ALK positive FFPE in the background of a negative FFPE.

Figure 3a

Figure 3a

Figure 3b

Figure 3c

Figure 3c

*For Research Use Only. Not for use in Diagnostic procedures.

QuantideX® NGS Reporter

Quantidex-Reporter-ComputerPush-button analytics & reporting suite – Set-up-and-go workflow designed for easy installation and implementation, right out of the box.

Runs directly on lab desktop – Install locally on a Windows® desktop computer. No prior bioinformatics experience or large server environments required.

Comprehensive reporting – Full bioinformatics and reporting of variants (SNVs, SNPs, Indels, fusions), and standard QC metrics are automatically calculated.

Integrates QuantideX RNA/DNA QC AssaySample-Aware™ bioinformatics with integrated functional template copy number analysis dramatically reduces false-call rates.

Seamless updates offered with new panel designs & variant annotation – Software updates allow new panels to be adopted without re-investing in analytics when the Asuragen QuantideX NGS product line is adopted.

Contact us to request the QuantideX Reporter

Resources

Videos

Evaluation of an NGS Assay for Detecting RNA Fusions and Splicing Events in Lung Cancer

Next-Generation Sequencing Within Your Reach: Targeted RNA Sequencing to Help Guide NSCLC Patient Care

Posters

Accurate and Reproducible Detection of Fusions and Exon Skipping Events in NSCLC-Derived Samples Using A Comprehensive, Targeted RNA-Seq System Across Multiple LaboratoriesView full poster

Head-To-Head Comparison of Two Commercially Available Next-Generation Sequencing Technologies That Detect Gene Fusions In Non-Small Cell Lung CancerView full poster

A Simple and Versatile Next-Generation Sequencing Technology for Co-Detection of RNA Structural Variants and DNA Mutations in Lung Cancer View full poster

Ordering

Product NameNumber of ReactionsCatalog Number
QuantideX NGS RNA Lung Cancer Kit*4849602
QuantideX NGS RNA Lung Cancer Kit*19249603

T 1-877-777-1874; 1-512-681-5200 F 1-512-681-5202 E orders@asuragen.com

View Sales Contacts

*For Research Use Only. Not for use in Diagnostic procedures.

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相关疾病:糖尿病心版战友请教一个病例,刚入院一COPD患者 ,长期服用类固醇类激素,现已有满月脸、中心性肥胖等皮质醇...
可以被直接吸收
教授给你们的知识教育给他们.也让他(她
)懂得一些道理或知识.
让世界充满爱不仅是付出,还可以是回报,回报你所关爱的人.
我记得有首歌曲,它的意思是爸爸妈妈辛苦了一天,回到家,帮他们拿拖鞋,帮他们倒杯茶,这是感
恩.老师批改作业累了,可以给他们捶捶背,当学习获得了一定的成功,老师会感到欣慰,这是感恩.当
同学遭遇困难时,你可以去用尽全力地安慰帮助他(她),使他(她)能够解决困难,克服困难,变得快
乐.这也是感恩.
固醇(sterol)   又称甾醇.类固醇的一种.固醇类化合物广泛分布于生物界.用脂肪溶剂提取动植物组织中的脂类,其中常有多少不等的、不能为碱所皂化的物质,它们均以环戊烷多氢菲为基本结构,并含有醇基,故称为固醇类化合物.胆固醇是高等动物细胞的重要组分.它与长链脂肪酸形成的胆固醇酯是血浆脂蛋白及细胞膜的重要组分.植物细胞膜则含有其它固醇如豆固醇及谷固醇.真菌和酵母则含有菌固醇.胆固醇是动物组织中其它固醇类化合物如胆汁醇、性激素、肾上腺皮质激素、维生素D3等的前体.   一类由 3个己烷环及一个环戊烷稠合而成的环戊烷多氢菲衍生物.除细菌中缺如外,广泛存在于动植物的细胞及组织中.固醇有多种不同的生物学功能,如作为细胞膜脂的成分及构成肾上腺皮质激素和性激素等.不少植物固醇还具有很强的药理或毒理效应,如洋地黄及哇巴因可增强心肌的收缩,是治疗心力衰竭的良药.植物中含β-谷固醇,酵母中含麦角固醇.动物中的固醇类以胆固醇的含量最丰富,它在体内可转变成固醇类激素──孕酮、雌二醇、睾酮、皮质醇及醛固酮等.许多避孕药物均属孕酮的衍生物;有的睾酮类似物则是体内蛋白质生物合成的促进剂.7-脱氢胆固醇在皮肤中经紫外线的照射可转变成维生素D3(胆钙化醇),后者在体内又可转变成调节钙磷代谢的激素──1,25-二羟胆钙化醇.引起昆虫蜕皮的蜕皮素及抗葡萄球菌的褐毒素也是固醇类化合物.哥伦布氏毒箭蛙(Phyllobates aurotaenia)分泌的蛙毒素仅需微量即可阻断神经冲动在神经肌肉间的传导.胆固醇在体内的代谢终产物是胆汁酸,而其他固醇类化合物则系经生物转化使其增加极性,排出体外.   甾醇是广泛存在于生物体内的一种重要的天然活性物质,按其原料来源和分为动物性甾醇、植物性甾醇和菌类甾醇等三大类.动物性甾醇以胆固醇为主,植物性甾醇主要为谷甾醇、豆甾醇和菜油甾醇等,而麦角甾醇则属于菌类甾醇.   植物甾醇广泛存在于植物的根、茎、叶、果实和种子中,是植物细胞膜的组成部分,在所有来源于植物种子的油脂中都含有甾醇.植物性甾醇不溶于水、碱和酸,但可以溶于乙醚、苯、氯仿、乙酸乙酯、石油醚等有机溶剂中.   生理功能  1. 预防心血管系统疾病 动物性食品摄入过多或人体调节功能出现障碍,会导致血清中胆固醇浓度过高,容易引发高血压及冠心病.植物甾醇可促进胆固醇的异化,抑制胆固醇在肝脏内的生物合成,并抑制胆固醇在肠道内的吸收,从而具有预防心血管疾病的作用.   2. 抑制肿瘤作用 植物甾醇具有阻断致癌物诱发癌细胞形成的功能,β-谷甾醇等植物甾醇对大肠癌、皮肤癌、宫颈癌的发生具有一定程度的抑制作用.
合成类固醇,如甲睾酮、苯丙酸诺龙灯;
非类固醇抗炎药 123
dfengg2021-07-27
非类固醇类抗炎药(NSAIDs)是具有抗炎、镇痛和退热功效的一大类药物,广泛应用于风湿科和骨科等领域。在国内医药市场中,有数十种NSAIDs。由于这类药物的作用机制相似,疗效和副作用大同小异,因此成了制药工业激烈竞争的焦点。例如,在国内外学术会议上,常有类似这样的情况:上午A公司的卫星会称A药有软骨保护作用,B药有软骨破坏作用;下午B公司的卫星会则称B药有软骨保护作用,A药有软骨破坏作用。都是出自著名专家的讲课,都有国际权威期刊的研究论文为依据,不少临床医师对此眼花缭乱,加上许多临床医师在NSAIDs方面的知识更新主要来自于制药公司的宣传,难免出现知识的偏倚。

为了帮助临床医师客观地了解NSAIDs,避开制药公司的导向以便更好地指导临床实践,本报请广州中山大学附属第一医院风湿免疫内科杨岫岩教授向读者介绍NSAIDs临床应用的一些问题。

NSAIDs的发展

从乙酰水杨酸(阿司匹林)应用至临床到现在,已经超过100个年头。1948年第一个非水杨酸类的NSAIDs保泰松问世后,抗炎镇痛药的种类迅速增加,如吲哚美辛、双氯芬酸、布洛芬、萘普生等,使NSAIDs“家族”迅速壮大。作为其“元老”的保泰松,虽然具有很强的抗炎镇痛作用,但潜在的严重副作用(再生障碍性贫血等)使其被淘汰。

1971年,环氧化酶(COX)理论解释了NSAIDs的作用机制。NSAIDs通过抑制COX,阻止花生四烯酸转变为前列腺素,后者既是炎症介质,又有生理功能。因此NSAIDs在抗炎镇痛的同时可引起胃肠道反应。20年后,研究者发现,COX存在不同的异构体,从而提出了COX异构体理论。认为COX存在两个异构体,一个是构建型的,称COX-1,以维持生理平衡为主;另一个是诱导型的称COX-2,主要参与炎症性前列腺素合成

1994年,氟舒胺成为第一个被报道在实验室证实具有选择性COX-2抑制作用的NSAIDs,但在1996年III期临床试验总结时发现,该药具有肝毒性而未能获准上市。1995年Lancet上首先称萘丁美酮、美洛昔康、尼美舒利等为“选择性COX-2抑制剂”,虽然同年该期刊刊出几篇读者来信,对此提法提出争议,但是后来人们仍普遍接受这种提法。1999年,针对COX异构体理论研制的昔布类药物(塞来昔布和罗非昔布)上市,被称为“特异性COX-2抑制剂”。

虽然COX异构体理论尚需完善,但它的确是新型NSAIDs研制的一个突破口。除已经问世的昔布类药物外,新的昔布类Etoricoxib、parecoxib、valdecoxib也将投入临床。新研制的COX-2抑制剂不只限于昔布类,磺酰苯胺类也是研制新型COX-2抑制剂的方向,如氟舒胺、NS-398、HN-56249等。另外,针对COX和脂氧化酶(5-lipoxygenase
下列物质中属于固醇类的物质是?
A.维生素
B.磷脂
C.菜油
D.猪油
相关疾病:家族性高胆固醇血症美国心脏病学学会(ACC)近日发布了有关非他汀类治疗降低低密度脂蛋白胆固醇(LDL-C)在心血管疾病...
你好, 固醇(sterol) 又称甾醇。类固醇的一种。固醇类化合物广泛分布于生物界。用碱性溶液提取动植物组织中的脂类,其中常有多少不等的、不能为碱所皂化的物质,它们均以环戊烷多氢菲为基本结构,并含有醇基,故称为固醇类化合物。胆固醇是高等动物细胞的重要组分。它与长链脂肪酸形成的胆固醇酯是血浆脂蛋白及细胞膜的重要组分。植物细胞膜则含有其它固醇如豆固醇及谷固醇。真菌和酵母则含有菌固醇。胆固醇是动物组织中其它固醇类化合物如胆汁醇、性激素、肾上腺皮质激素、维生素D3等的前体,希望能帮到你。