GradeMolecular Biology Grade
Specification
Appearance | White powder |
Mol. Formula | Not applicable. A polysaccharide complex. |
Mol. Weight | Not Applicable. |
Assay | Min | Max | Units |
Moisture content (≤ 10) | <10 | % | |
Sulfate content (≤ 0.15) | <0.15 | % | |
Gel Strength, 1.0% (≥ 1200) | 1340 | 2910 | g/cm2 |
EEO | 0.12 | -mr | |
Gelling Temperature | 36.0 | 37.0 | ˚C |
Melting Temperature | ≤90 | ˚C | |
Appearance | PASS | ||
RNase / DNase | Not Detected |
Ordering Information
Catalog No | Description | Pack Size |
PC0701-100g | Agarose (Molecular Biology Grade) | 100g |
PC0701-500g | Agarose (Molecular Biology Grade) | 500g |
PC0701-1kg | Agarose (Molecular Biology Grade) | 1kg |
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Agarose (Molecular Biology Grade)
PublicationThis Product Has Been Used In: Alshaibani et al. (2020) An improved procedure for the isolation of Ribonucleic acid from methicillin-resistant Staphylococcus aureus, Novel Research in Microbiology Journal, 4(2):704-713.Erkihun A & Kausalya R (2020) MCR-1 Gene Encoded Colistin-Resistant Escherichia coli in Raw Chicken Meat and Bean Sprouts in Malaysia, International Journal of Microbiology, Article ID 8853582.Lee Q et al. (2020) Murine and Related Chapparvoviruses are Nephro-tropic and Produce Novel Accessory Proteins in Infected Kidneys, PLOS Pathogens, 16(1): e1008262.Thongkao, K. & Sudjaroen, Y. (2020) Screening of antibiotic resistance genes in pathogenic bacteria isolated from tiny freshwater shrimp (Macrobrachium lanchesteri) and “Kung Ten”, the uncooked Thai food,Journal of Advanced Veterinary and Animal Research, 7(1):83-91Wannapa, Settheetham-Ishida et al. (2020)Genetic Polymorphism of Glutathione S-transferase and Cervical Cancer Susceptibility in Northeastern Thailand, Asian Pacific Journal of Cancer Biology, 5(2): 35-41.Tung HJ et al. (2019)cDNA-SSR Markers for Molecular Epidemiology of Ganoderma boninense,. Journal of Oil Palm Research, 31(2):220-237.Weiming, Su J. et al. (2019) Depth-sensitive Raman spectroscopy for skin wound evaluation in rodents, . Biomedical Optics Express, 10(12):6114-6128.Bo, E., Wang, L., Wu, X., Luo, Y., Chen, S., Chen, S., Liang, H., Ni, G., Yu, X., Liu, L. (2018) . Multiple aperture synthetic optical coherence tomography for biological tissue imaging, , Optics Express, Vol. 26, No. 2 (2018).Wong, C.Y. et al. (2018)Identification of Klebsiella pneumoniae in microwavable chicken curries using 16s rRNA analysis. International Food Research Journal, 25(2):620-625.Bo, E., Luo, Y., Chen, S., Liu, X., Wang, N., Gen, X. (2017).Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis, Optica, Vol. 4, No. 7, 701-706 (2017).Chakdar, H., Pabbi, S. (2017).A comparative study reveals the higher resolution of RAPD over ARDRA for analyzing diversity of Nostoc strains,Springer,Vol. 7, No. 125. (2017).Chong,S.Y., Rao, P.V., Soon, J.M. (2017). Identification of Escherichia spp. strains in street-vended beverages and associated preparation surfaces using 16S rRNA analysis, International Food Research Journal, Vol. 4, No. 4, 1811-1818 CRivera, M.P., Cardenas, L.B. (2017). Species Delineation of Kaempferia galanga L. and Kaempferia pulchra L. in the Phillipines using psbA-trnH and petA-psbL-psbJ, . Biomedical Research, Vol. 16, No. 2., 84-93 (2017). Suleiman, E.A., Abdalla, W.G., Ahmed, A.H., Abdelgabar, M.A. (2017).Isolation and Molecular Characterization of Dermatophytes in Donkeys, , International Journal of Tropical Disease and Health, Vol. 26, No. 4, 1-8 (2017). Widyaningtyas, S.T., Soebandrio, F., Ibrahim, F., Bela, B. (2017). Design, synthesis, and functional testing of recombinant cell penetrating peptides. . Journal of Physics. (2017) Abu-Elsaad,N.M., Serrya, M.S., El-Karef, A.M., Ibrahim, T.M. (2016) The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice, Pharmacological Reports 68 (2016). 275–282 Aras, B., & Yerlikaya, A. (2016) Bortezomib and Etoposide Combinations Exert Synergistic Effects on the Human Prostate Cancer Cell Line PC-3. Oncology Letters. 11, p. 3179-3184.Luang-In,V., Deeseenthum, S. (2016) Exopolysaccharide-producing isolates from Thai milk kefir and their antioxidant activities. . LWT - Food Science and Technology.73. Pp592-601 Merghani, E.A.E., Elsanousi, S.M., Hamedelnil, Y.F., Gornas, N.A. (2016).Molecular Study of Bacterial Pathogens Isolated From Haemodialysis Patients, Sudan Journal of Science and Technology, Vol 12, No. 1, 1-10 (2016).Shamila-Syuhada, A.K., Rusul, G., Wan-Nadiah, W.A., Chuah, L. (2016).Prevalence and Antibiotics Resistance of Staphylococcus aureus Isolates Isolated from Raw Milk Obtained from Small-Scale Dairy Farms in Penang, Malaysia, Pakistan Veterinary Journal, Vol. 36, No. 1, 98-102 (2016). Vikneswaran, R., Eltayeb, N.E., Ramesh S., Yahya, R. (2016) New alicyclic thiosemicarbazone chelated zinc(II) antitumor complexes: Interactions with DNA/protein, nuclease activity and inhibition of topoisomerase-I. Polyhedron.105. Pp.89-95Wang, Z., Yang, T.D., S, A.S., Chang, M.S., Kershaw, S.V., Lo, P.K., Rogach, A.L. (2016) ) Aggregation-free DNA nanocage/Quantum Dot complexes based on electrostatic. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 495. Pp62-67.Watanapokasin, R., Imoto, M., Innajak, S., Kritsanawong, S. (2016).Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells, International Journal of Oncology, Vol. 48, No. 5 (2016). Ahmad, A.A.A.M., El-Obeid, E.A., Abushama, H. (2015). The Incidence of F8 Gene Mutation In Sudanese Patients at risk of both venous and arterial thrombosis under prolong use of Warfarin treatment, World Journal of Pharmaceutical Research, Vol. 3, No. 4, 27-34 (2017). Kepel, B., & Fatimawali, D. (2015) Analysis of 16SrNA Gene and Mercury Reduction Ability of Mercury Resistant Bacteria Isolated from Feces of Patient with Mercury Amalgam at Puskesmas Bahu in Manado. Jurnal Kedokteran Yarsi23(1), p.45-55.Malaitad, T., Poeaim, S., Eiamampai, K. (2015).Sex identification in barn swallows (Hirundorustica Linnaeus) by molecular technique, Journal of Agricultural Techonology, Vol. 11, No. 8, 2411-2418 (2015).Rahman, R.A., Sukri, N.M., Nazir, N.M., Aa’zamuddin, M., Radzi, A., Zulkifly, A.H., Ahmad, A.C., Hashi, A.A., Rahman, S.A., Sha’ban, M. (2015). The potential of 3-dimensional construct engineered from poly(lactic-co-glycolic acid)/fibrin hybrid scaffold seeded with bone marrow mesenchymal stem cells for in vitro cartilage tissue engineering. Tissue and Cell 47 (4). Pp.420-430Saeed, I.K., et al (2015) First Report of Bovine Viral Diarrhea Virus Antigen from Pneumonic Cattle in Sudan Journal of Advanced Veterinary and Animal Research2(2), p.153-157. Vikneswaran, R., Syafiq, M.S., Eltayeb, N.E., Kamaruddin, M.N., Ramesh, S., Yahya, R. (2015)) A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 150. Pp.175-180.Cerasi, M., et al. (2014) The ZupT Transporter Plays an Important Role in Zinc Homeostasis and Contributes to Salmonella enterica Virulence. Metallomics. 6(4), p.845-853.Chan, S.N., et al. (2014) Molecular Cloning and Characterization of Novel Phytocystatin Gene from Turmeric, Curcuma longa. BioMed Research International. Hassanin, A., et al. (2014) Heparin Modulation on Hepatic Nitric Oxide Synthase in Experimental Steatohepatitis. Experimental and Theapeutic Medicine8, p. 1551-1558.Kaoud, H.A., Hussein, H.A., El-Dahshan, A.R., Kaliefa, H.S., Rohaim, M.A.(2014)Co-circulation of avian influenza viruses in commercial farms, backyards and live market birds in Egypt. International Journal of Veterinary Science and Medicine. 2(2). Pp.114-121Yuen, C. Liu, Q. (2014). Towards in vivo intradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe, Journal of Biophotonics, Vol. 7, No. 9, 683-689 (2014).Nazree, N.E., et al. (2013) Lack of Association Between TPH2 Gene Polymorphisms with Major Depressive Disorder in Multiethnic Malaysia Population Asia-Pacific Psychiatryp.1-6. Rianthavorn, P., Chokedeemeeboon, C., Deekajorndech, T., Suphapeetiporn, K. (2013) Interleukin-10 promoter polymorphisms and expression in Thai children with juvenile systemic lupus erythematosus. Lupus. 22. Pp.721-726Supathaweewat, K., Klanrit, P (2013). cDNA cloning and expression analyses of phytoene synthase 1, phytoene desaturase and -carotene desaturase genes from Solanum lycopersicum KKU-T34003, Songklankarin Journal of Science and Technology, Vol. 35, No. 5, 517-527 (2013).
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http://care.diabetesjournals.org/cgi/content/abstract/31/8/1479
OBJECTIVE—Hyperglycemiaisariskfactorformicrovascularcomplicationsandmayincreasetheriskofcardiovasculardiseaseinpatientswithtype2diabetes.ThisstudytestedtheLDLcholesterol–loweringagentcolesevelamHCl(colesevelam)asapotentialnoveltreatmentforimprovingglycemiccontrolinpatientswithtype2diabetesonsulfonylurea-basedtherapy.
RESEARCHDESIGNANDMETHODS—A26-week,randomized,double-blind,placebo-controlled,parallel-group,multicenterstudywascarriedoutbetweenAugust2004andAugust2006toevaluatetheefficacyandsafetyofcolesevelamforreducingA1Cinadultswithtype2diabeteswhoseglycemiccontrolwasinadequate(A1C7.5–9.5%)withexistingsulfonylureamonotherapyorsulfonylureaincombinationwithadditionaloralanti-diabetesagents.Intotal,461patientswererandomized(230givencolesevelam3.75g/dayand231givenplacebo).Theprimaryefficacymeasurementwasmeanplacebo-correctedchangeinA1Cfrombaselinetoweek26intheintent-to-treatpopulation(lastobservationcarriedforward).
RESULTS—Theleastsquares(LS)meanchangeinA1Cfrombaselinetoweek26was–0.32%inthecolesevelamgroupand+0.23%intheplacebogroup,resultinginatreatmentdifferenceof–0.54%(P<0.001).TheLSmeanpercentchangeinLDLcholesterolfrombaselinetoweek26was–16.1%inthecolesevelamgroupand+0.6%intheplacebogroup,resultinginatreatmentdifferenceof–16.7%(P<0.001).FurThermore,significantreductionsinfastingplasmaglucose,fructosamine,totalcholesterol,non–HDLcholesterol,andapolipoproteinBweredemonstratedinthecolesevelamrelativetoplacebogroupatweek26.
CONCLUSIONS—ColesevelamimprovedglycemiccontrolandreducedLDLcholesterollevelsinpatientswithtype2diabetesreceivingsulfonylurea-basedtherapy.
为了帮助临床医师客观地了解NSAIDs,避开制药公司的导向以便更好地指导临床实践,本报请广州中山大学附属第一医院风湿免疫内科杨岫岩教授向读者介绍NSAIDs临床应用的一些问题。
NSAIDs的发展
从乙酰水杨酸(阿司匹林)应用至临床到现在,已经超过100个年头。1948年第一个非水杨酸类的NSAIDs保泰松问世后,抗炎镇痛药的种类迅速增加,如吲哚美辛、双氯芬酸、布洛芬、萘普生等,使NSAIDs“家族”迅速壮大。作为其“元老”的保泰松,虽然具有很强的抗炎镇痛作用,但潜在的严重副作用(再生障碍性贫血等)使其被淘汰。
1971年,环氧化酶(COX)理论解释了NSAIDs的作用机制。NSAIDs通过抑制COX,阻止花生四烯酸转变为前列腺素,后者既是炎症介质,又有生理功能。因此NSAIDs在抗炎镇痛的同时可引起胃肠道反应。20年后,研究者发现,COX存在不同的异构体,从而提出了COX异构体理论。认为COX存在两个异构体,一个是构建型的,称COX-1,以维持生理平衡为主;另一个是诱导型的称COX-2,主要参与炎症性前列腺素合成。
1994年,氟舒胺成为第一个被报道在实验室证实具有选择性COX-2抑制作用的NSAIDs,但在1996年III期临床试验总结时发现,该药具有肝毒性而未能获准上市。1995年Lancet上首先称萘丁美酮、美洛昔康、尼美舒利等为“选择性COX-2抑制剂”,虽然同年该期刊刊出几篇读者来信,对此提法提出争议,但是后来人们仍普遍接受这种提法。1999年,针对COX异构体理论研制的昔布类药物(塞来昔布和罗非昔布)上市,被称为“特异性COX-2抑制剂”。
虽然COX异构体理论尚需完善,但它的确是新型NSAIDs研制的一个突破口。除已经问世的昔布类药物外,新的昔布类Etoricoxib、parecoxib、valdecoxib也将投入临床。新研制的COX-2抑制剂不只限于昔布类,磺酰苯胺类也是研制新型COX-2抑制剂的方向,如氟舒胺、NS-398、HN-56249等。另外,针对COX和脂氧化酶(5-lipoxygenase
B、是重要的储能物质,磷脂为构成生物膜的重要成分,固醇为动物细胞膜的构成物质及形成激素等,B错误;
C、蛋白质是细胞代谢的主要结构物质,糖类是细胞代谢的主要能源物质C错误;
D、ATP的结构简式是 A-P~P~P,其中A代表腺苷,腺苷是构成ATP的重要部分,D正确.
故选:D.
多肽和蛋白质类激素(不可口服):促甲状腺激素释放激素,促甲状腺激素,促性腺激素、生长激素,催乳素,胰岛素,胰高血糖素,
氨基酸类衍生物(可口服):甲状腺激素、肾上腺素
脂质类激素:(可口服)性激素和孕激素
蛋白质类激素不能口服,因会被消化液中的蛋白酶分解(——这是原因)
这是我们老师说的哦!!希望对你有帮助