850356 | 4ME 16:0 PC
1,2-diphytanoyl-sn-glycero-3-phosphocholine
4ME 16:0 PC
1,2-diphytanoyl-sn-glycero-3-phosphocholine
Lipids containing diphytanoyl fatty acid chains have been used to produce stable planar lipid membranes (see References). Diphytanoyl phosphatidylcholine does not exhibit a detectable gel to liquid crystalline phase transition from -120°C to +120°C.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC"s. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis. Several of these products are manufactured under the current guidelines of Good Manufacturing Practice and are available for pharmaceutical use. If you have a requirement for a choline derivative not found on our list, please call us: custom synthesis is one of our specialties.
- ChemDraw File
- 3D Structure
- Structure
- Transition Temperature Of Diphytanoyl Pc
- Safety Data Sheet
- Safety Data Sheet
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PubMed ID: 31070654Puthumadathil N, Jayasree P, Santhosh Kumar K, Nampoothiri KM, Bajaj H, Mahendran KR. Detecting the structural assembly pathway of human antimicrobial peptide pores at single-channel level. Biomater Sci. 2019 Jun 5. doi: 10.1039/c9bm00181f. [Epub ahead of print]
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PubMed ID: 30820470Inada M, Kinoshita M, Sumino A, Oiki S, Matsumori N. A concise method for quantitative analysis of interactions between lipids and membrane proteins. Anal Chim Acta. 2019 Jun 20;1059:103-112. doi: 10.1016/j.aca.2019.01.042. Epub 2019 Feb 1.
PubMed ID: 30876624Huang G, Voet A, Maglia G. FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution. Nat Commun. 2019 Feb 19;10(1):835. doi: 10.1038/s41467-019-08761-6.
PubMed ID: 30783102Krishnan R S, Satheesan R, Puthumadathil N, Kumar KS, Jayasree P, Mahendran KR. Autonomously Assembled Synthetic Transmembrane Peptide Pore. J Am Chem Soc. 2019 Feb 20;141(7):2949-2959. doi: 10.1021/jacs.8b09973. Epub 2019 Feb 12.
PubMed ID: 30702873Huang G, Voet A, Maglia G. FraC nanopores with adjustable diameter identify the mass of opposite-charge peptides with 44 dalton resolution. Nat Commun. 2019 Feb 19;10(1):835. doi: 10.1038/s41467-019-08761-6.
PubMed ID: 30783102Krishnan R S, Satheesan R, Puthumadathil N, Kumar KS, Jayasree P, Mahendran KR. Autonomously Assembled Synthetic Transmembrane Peptide Pore. J Am Chem Soc. 2019 Feb 20;141(7):2949-2959. doi: 10.1021/jacs.8b09973. Epub 2019 Feb 12.
PubMed ID: 30702873Dugger ME, Baker CA. Automated formation of black lipid membranes within a microfluidic device via confocal fluorescence feedback-controlled hydrostatic pressure manipulations. Anal Bioanal Chem. 2019 Jan 7. doi: 10.1007/s00216-018-1550-4. [Epub ahead of print]
PubMed ID: 30617393Mohid SA, Ghorai A, Ilyas H, Mroue KH, Narayanan G, Sarkar A, Ray SK, Biswas K, Bera AK, Malmsten M, Midya A, Bhunia A. Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy. Colloids Surf B Biointerfaces. 2019 Jan 8;176:360-370. doi: 10.1016/j.colsurfb.2019.01.020. [Epub ahead of print]
PubMed ID: 30658284Bhamidimarri SP, Zahn M, Prajapati JD, Schleberger C, Söderholm S, Hoover J, West J, Kleinekathöfer U, Bumann D, Winterhalter M, van den Berg B. A Multidisciplinary Approach toward Identification of Antibiotic Scaffolds for Acinetobacter baumannii. Structure. 2019 Feb 5;27(2):268-280.e6. doi: 10.1016/j.str.2018.10.021. Epub 2018 Dec 13.
PubMed ID: 30554842Golla VK, Sans-Serramitjana E, Pothula KR, Benier L, Bafna JA, Winterhalter M, Kleinekathöfer U. Fosfomycin Permeation through the Outer Membrane Porin OmpF. Biophys J. 2019 Jan 22;116(2):258-269. doi: 10.1016/j.bpj.2018.12.002. Epub 2018 Dec 8.
PubMed ID: 30616836Yang J, Wang Y, Li M, Ying YL, Long YT. Direct Sensing of Single Native RNA with a Single-Biomolecule Interface of Aerolysin Nanopore. Langmuir. 2018 Nov 21. doi: 10.1021/acs.langmuir.8b03264. [Epub ahead of print].
PubMed ID: 30462509Chengxiang Zhang, Weiyu Zhao , Cong Bian, Xucheng Hou, Binbin Deng, David W. McComb, Xiaofang Chen, and Yizhou Dong. Antibiotic-Derived Lipid Nanoparticles to Treat Intracellular Staphylococcus aureus. ACS Appl. Bio Mater., Article ASAP
Challita EJ, Freeman EC. Hydrogel Microelectrodes for the Rapid, Reliable, and Repeatable Characterization of Lipid Membranes. Langmuir. 2018 Nov 23. doi: 10.1021/acs.langmuir.8b02867. [Epub ahead of print]
PubMed ID: 30468580Patrick Urban, Stefanie D. Pritzl, David B. Konrad, James A. Frank, Carla Pernpeintner, Christian R. Roeske, Dirk Trauner, and Theobald Lohmueller. Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles. Langmuir, Just Accepted Manuscript. DOI: 10.1021/acs.langmuir.8b03241. Publication Date (Web): October 10, 2018
PubMed ID: 30346771Sacconi A, Tadini-Buoninsegni F, Tiribilli B, Margheri G. A Comparative Study of Phosphatidylcholine versus Phosphatidylserine-based Solid Supported Membranes for the Preparation of Liposome-Rich Interfaces. Langmuir. 2018 Sep 14. doi: 10.1021/acs.langmuir.8b02397. [Epub ahead of print]
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PubMed ID: 5579131Transition Temperature Of Diphytanoyl Pc
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AvantiPolarLipids公司是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供1000种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，AvantiPolarLipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。 AvantiPolarLipids,Inc.,hasalonghistoryof50yearscreatingthehighestpuritylipidsavailable.Ourpassionforhighqualityanduniqueproductsisonlyexceededbyourexcellentreputationinthemarketplace. Althoughweareknownforourlipids,weareMorethanLipids.Weoffersolutionsfortheentireproductcycle…ResearchtoCommercialization. AvantiPolarLipids公司的主要产品和服务包括：（1）ResearchProductsHighestPurityLipidReagents（2）cGMPManufacturingAPI&ContractManufacturing（3）AdjuvantsImmunotherapy&VaccineDevelopment（4）AnalyticalServicesLipidAnalysis（5）LipidomicsMassSpecStandards,Antibodies&LipidToolbox（6）Formulationsliposomes&Nanoparticles（7）EquipmentLiposomeProductionTools（8）CustomServicesSynthesis&Beyond
AvantiPolarLipids是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供1000种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，AvantiPolarLipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。
AvantiPolarLipidsInc,是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至百公斤级的磷脂类和甾体类中间体和试剂。主要产品Naturalsphingolipids天然鞘脂类Naturalphospholipids天然磷脂类Naturallipidsbyextraction天然提取脂类Referencestandards相关标准品Syntheticsphingolipids合成鞘脂类--Sphingosines&S-1-P鞘氨醇和鞘氨醇-1-磷酸盐--Ceramides神经酰胺--Sphingomyelins鞘磷脂--Sphingosine&ceramidederivatives鞘氨醇及神经酰胺衍生物--Sphinganine&derivatives鞘氨醇及其衍生物--C17sphingolipids十七碳鞘脂类--C20sphingolipids二十碳鞘脂类--Phytosphingosine&derivatives植物鞘氨醇及其衍生物Syntheticlipids&phospholipids合成脂质与磷脂--PC卵磷脂--PA磷脂酸--PE脑磷脂--PG磷脂酰甘油--PS磷脂酰丝氨酸--PI,PIP2&PIP3磷脂酰肌醇，磷脂酰肌醇-4,5-二磷酸，磷脂酰-3,4,5-三磷酸--CA胆酸--LysoPC溶源性卵磷脂--LysoPA溶源性磷脂酸--LysoPAAnalogues溶源性磷脂酸类似物--Lysobio-PA溶源性双磷脂酸--LysoPE,PG&PS溶源性脑磷脂，磷脂酰甘油和磷脂酰丝氨酸--AlkylPC烷基卵磷脂--Diether&Diphytanoyletherlipids二醚与二植烷醚脂质--PAF血小板活化因子--AcylPAFAnalog酰化血小板活化因子类似物--Brominatedphosphocholines溴代胆碱磷酸--Alkylphosphatederivatives烷基磷酸盐衍生物--Plasmalogen缩醛磷脂--Functionalizedlipids功能性脂类--Biotinylatedlipids生物素酰化脂质--Bioactivelipids生物活性脂类Syntheticphospholipids合成磷酸--AcylcoenzymeA乙酰辅酶A--Metabolicintermediates代谢中间产物--Adhesivelipid粘合脂质--pHsensitivelipids酸度计用脂质Transfectionreagents转染试剂Sterolderivatives甾酮衍生物Lipidblends混合脂质Glycosylatedphospholipids糖化磷脂Fluorinatedphospholipids氟化磷脂Chelators螯合剂Pre-mixedlipidsforbicelleformation构型分析用预混合脂质Diacylglycerols&analogues甘油二酯与类似物Deuteriumlabeledlipids氘标记脂质C13PC碳-13标记卵磷脂DoxylPC自旋标记卵磷脂TempoPCTempo（4-氧-4-羟-四甲基呱啶氮氧自由基）标记卵磷脂Fluoresecentsphingolipids荧光标记鞘脂类--Omegalabeled欧米加标记物--Fattyacidlabeled脂肪酸标记物Fluoresecentcholesterol荧光标记胆固醇Fluoresecentphospholipids荧光标记磷脂--Fattyacidlabeled脂肪酸标记物--Headgrouplabeled首基标记物Polymerizablelipids聚合脂质Poly（Ethyleneglycol）-lipidconjugates共轭聚脂质FunctionalizedPEGlipids功能PEG脂质Analyticalservices分析服务Drugdeliveryproduct药物运送载体Bulklipidsforpharmaceuticalproduction工业级脂质Equipment设备
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为了帮助临床医师客观地了解NSAIDs，避开制药公司的导向以便更好地指导临床实践，本报请广州中山大学附属第一医院风湿免疫内科杨岫岩教授向读者介绍NSAIDs临床应用的一些问题。
NSAIDs的发展
从乙酰水杨酸（阿司匹林）应用至临床到现在，已经超过１００个年头。１９４８年第一个非水杨酸类的ＮＳＡＩＤｓ保泰松问世后，抗炎镇痛药的种类迅速增加，如吲哚美辛、双氯芬酸、布洛芬、萘普生等，使ＮＳＡＩＤｓ“家族”迅速壮大。作为其“元老”的保泰松，虽然具有很强的抗炎镇痛作用，但潜在的严重副作用（再生障碍性贫血等）使其被淘汰。
１９７１年，环氧化酶（ＣＯＸ）理论解释了ＮＳＡＩＤｓ的作用机制。ＮＳＡＩＤｓ通过抑制ＣＯＸ，阻止花生四烯酸转变为前列腺素，后者既是炎症介质，又有生理功能。因此ＮＳＡＩＤｓ在抗炎镇痛的同时可引起胃肠道反应。２０年后，研究者发现，ＣＯＸ存在不同的异构体，从而提出了ＣＯＸ异构体理论。认为ＣＯＸ存在两个异构体，一个是构建型的，称ＣＯＸ－１，以维持生理平衡为主；另一个是诱导型的称ＣＯＸ－２，主要参与炎症性前列腺素合成。
１９９４年，氟舒胺成为第一个被报道在实验室证实具有选择性ＣＯＸ－２抑制作用的ＮＳＡＩＤｓ，但在１９９６年ＩＩＩ期临床试验总结时发现，该药具有肝毒性而未能获准上市。１９９５年Ｌａｎｃｅｔ上首先称萘丁美酮、美洛昔康、尼美舒利等为“选择性ＣＯＸ－２抑制剂”，虽然同年该期刊刊出几篇读者来信，对此提法提出争议，但是后来人们仍普遍接受这种提法。１９９９年，针对ＣＯＸ异构体理论研制的昔布类药物（塞来昔布和罗非昔布）上市，被称为“特异性ＣＯＸ－２抑制剂”。
虽然ＣＯＸ异构体理论尚需完善，但它的确是新型ＮＳＡＩＤｓ研制的一个突破口。除已经问世的昔布类药物外，新的昔布类Ｅｔｏｒｉｃｏｘｉｂ、ｐａｒｅｃｏｘｉｂ、ｖａｌｄｅｃｏｘｉｂ也将投入临床。新研制的ＣＯＸ－２抑制剂不只限于昔布类，磺酰苯胺类也是研制新型ＣＯＸ－２抑制剂的方向，如氟舒胺、ＮＳ－３９８、ＨＮ－５６２４９等。另外，针对ＣＯＸ和脂氧化酶（５－ｌｉｐｏｘｙｇｅｎａｓｅ
第一类激素作用在靶细胞表面,并不进入细胞内部,而是与细胞膜表面特异的受体结合.这种结合使腺苷酸环化酶激活产生cAMP(一种第二信使),cAMP再去激活细胞内的一些特定系列的酶,从而引起各种生理效应.这是由E.W.Sutherland于1965年提出来的第二信使假说
第二类激素由于是脂溶性的小分子.能直接进入靶细胞,与靶细胞的细胞质中的受体分子结合成"激素-受体复合物",在一定条件下穿过核膜进入核内,与染色质上的一种酸性蛋白质相互作用,促进DNA样板转录相应的mRNA.
mRNA扩散出核膜进入细胞质,导致某种蛋白质(酶)的合成,从而引起这种激素的生理效应.
这个“类”是什么意思？
B、是重要的储能物质，磷脂为构成生物膜的重要成分，固醇为动物细胞膜的构成物质及形成激素等，B错误；
C、蛋白质是细胞代谢的主要结构物质，糖类是细胞代谢的主要能源物质C错误；
D、ATP的结构简式是 A-P～P～P，其中A代表腺苷，腺苷是构成ATP的重要部分，D正确．
故选：D．
磷脂C、H、O、N、P固醇C、H、ODNA 和RNA一样 CHONP
