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R&D Systems/Human ErbB4/Her4 AlexaFluor®700-conjugated Antibody/FAB11311N-100/100 Tests

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R&D Systems/Human ErbB4/Her4 AlexaFluor®700-conjugated Antibody/FAB11311N-100/100 Tests

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rndsystems

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FAB11311N-100-100Tests

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SpeciesReactivity
Human
Specificity
DetectshumanErbB4/Her4indirectELISAsandWesternblots.IndirectELISAsandWesternblots, nocross-reactivitywithrecombinanthuman(rh) EGFR,rhErbB2,orrhErbB3isobserved.
Source
MonoclonalMouseIgG_2AClone#182818
Purification
ProteinAorGpurifiedfromhybridomaculturesupernatant
Immunogen
MousemyelomacelllineNS0-derivedrecombinanthumanErbB4/Her4
Glu26-Arg649
Accession#Q15303
Formulation
SuppliedinasalinesolutioncontainingBSAandSodiumAzide.
Label
AlexaFluor700

FlowCytometry
5µL/10⁶cells
Seebelow

Shipping
Theproductisshippedwithpolarpacks.Uponreceipt,storeitimmediatelyatthetemperaturerecommendedbelow.
StABIlity&Storage
Protectfromlight.Donotfreeze.
- 12monthsfromdateofreceipt,2to8°Cassupplied.

References:
1. Plowman,G.D.etal.(1993)Proc.Natl.Acad.Sci.USA90:1746.
2. Elenius,K.etal.(1997)J.Biol.Chem.272:26761.
3. Elenius,K.etal.(1999)Oncogene18:2607.
4. Rio,C.etal.(2000)J.Biol.Chem.275:10379.
5. Emkey,R.andC.R.Kahn(1997)J.Biol.Chem.272:31172.
6. Sundaresan,S.etal.(1998)Endocrinology139:4756.
7. Schaefer,G.etal.(1999)J.Biol.Chem.274:859.
8. Schlessinger,J.(2000)Cell103:211.
9. Daly,R.J.(1999)GrowthFactors16:255.
LongName:
ReceptorTyrosineProteinKinaseErbB4
EntrezGeneIDs:
2066(Human);13869(Mouse);59323(Rat)
AlternateNames:
avianerythroblasticleukemiaviral(v-erb-b2)oncogenehomolog4;EC2.7.10;EC2.7.10.1;ErbB4;HER4;HER4MGC138404;p180erbB4;Proto-oncogene-likeproteinc-ErbB-4;receptortyrosine-proteinkinaseerbB-4;Tyrosinekinase-typecellsurfacereceptorHER4;v-erb-aavianerythroblasticleukemiaviraloncogenehomolog-like4;v-erb-aerythroblasticleukemiaviraloncogenehomolog4(avian)

Background:

ErbB4,alsocalledHer4(humanepidermalgrowthfactorreceptor4),isatypeImembraneglycoproteinthatisamemberoftheErbBfamilyoftyrosinekinasereceptors.ErbBfamilymembersserveasreceptorsfortheepidermalgrowthfactor(EGF)familyofgrowthfactors.ErbB4isexpressedinnormalskeletalmuscle,heart,pituitary,brainandseveralbreastcarcinomas.ErbB4ligandsincludetheneuregulins,beta-cellulinandheparin-bindingEGF-likegrowthfactor(HB-EGF).MonomericErbB4bindsitsligandswithlowaffinity.Typically,heterodimerizationwithErbB2formsthehighaffinityreceptorcomplex.However,ErbB4hasalsobeenshowntoheterodimerizewithbothErbB1andErbB3.Ithasbeensuggestedthattheidentityoftheligandmayinfluencethedimerizationpartner.SeveralErbB4isoformsexist.TwoofthesedifferinthepresenceofjuxtamembraneextracellularsequenceswhichregulatetheabilityofTACE(TNF-alphaconvertingenzyme,ADAM17)toproteolyticallycleaveErbB4fromthecellsurface.Theseisoformsexhibittissue-specificexpression.Anotherisoformlacksthephosphoinositide3-kinaseactivationsequencepresentintheErbB4cytoplasmicdomain.HumanErbB4consistsof1308aminoacids(aa)witha25aasignalsequence,a626aaextracellulardomain,a24aatransmembraneregion,anda633aacytoplasmicdomain.ErbB4appearstoplayimportantrolesinneuronaldevelopment,developmentoftheheartandcancer.

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