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R&D Systems/Recombinant Human XCL2/SCM-1 beta Protein/8418-X2-025/CF/25 ug

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R&D Systems/Recombinant Human XCL2/SCM-1 beta Protein/8418-X2-025/CF/25 ug

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rndsystems

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8418-X2-025/CF-25ug

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Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 eu="" per="" 1="" μg="" of="" the="" protein="" by="" the="" lal="">
Activity
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human XCR1. The ED₅₀ for this effecy is 10-60 ng/mL.
Source
Human embryonic kidney cell, HEK293-derived Val22-Gly114
Accession #
Q9UBD3
N-terminal Sequence
Analysis
Val22
Predicted Molecular Mass
10 kDa
SDS-PAGE
19-22 kDa, reducing conditions

References:
1. Yoshida, T. et al. (1996) FEBS Lett. 395:82.
2. Kelner, G.S. et al. (1994) Science 266:1395.
3. Muller, S. et al. (1995) Eur. J. Immunol. 25:1744.
4. Yoshida, T. et al. (1995) FEBS Lett. 360:155.
5. Hedrick, J.A. et al. (1997) J. Immunol. 158:1533.
6. Luzi, G. et al. (2007) Clin. Immunol. 125:127.
7. Cao, W. et al. (2008) Curr. Microbiol. 57:189.
8. Kroczek, R.A. and V. Henn (2012) Front. Immunol. 3:14.
9. Huang, H. et al. (2001) Biochem. Biophys. Res. Commun. 281:378.
10. Pigard, N. et al. (2009) J. Neuroimmunol. 209:114.
11. Yamazaki, C. et al. (2010) Biochem. Biophys. Res. Commun. 397:756.
12. Kim, M. et al. (2012) Mol. Cancer. Res. 10:1419.
Long Name:
XCL 2/SCM-1 beta
Entrez Gene IDs:
6846 (Human)
Alternate Names:
C motif chemokine 2; chemokine (C motif) ligand 2; cytokine SCM-1 beta; SCM1 beta; SCM-1 beta; SCM1B; SCM-1b; SCYC2; SCYC2XC chemokine ligand 2; small inducible cytokine subfamily C, member 2; XCL2

Background:

Human XCL2 (also known as Lymphotactin-2, SCYC2, and SCM-1 beta ) is a 10 kDa glycosylated protein in the C chemokine family (1-3). XCL1/Lymphotactin is a closely related chemokine that differs from XCL2 by only two amino acids (aa). Human XCL2 encodes a 114 amino acid aa precursor protein with a 21 aa predicted signal peptide. Members of the C chemokine family lack two (the 1^st and 3^rd) of the four invariant cysteine residues normally found in the CC and CXC chemokines. They also have an extended carboxy terminus (4). XCL1/Lymphotactin which is expressed in activated T cells and NK cells, while certain stimulatory conditions have been shown to induce XCL2 expression in macrophages (5-7). XCL2 and XCL1/Lymphotactin bind and activate the G protein-coupled receptor, XCR1. XCR1 is expressed on dendritic cells, T lymphocytes, and B lymphocytes (8-11). Binding of XCL2 to XCR1 initiates chemotaxic cell migration in dendritic cells as well as in T and B lymphocytes. XCR1 is also expressed on ovarian carcinoma cells and may contribute to cancer cell migration and proliferation in response to XCL2 or XCL1/Lymphotactin (12).

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