为什么甲亢时ACTH，尿17羟，尿17酮早期增多晚期减少？

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2016-06-22

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书上没有相关说法，求解

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Teanie

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决定20 书上没有相关说法，求解TH对垂体ACTH影响通过：1、通过影响外周皮质醇代谢间接影响ACTH释放（TH分泌增多患者BMI增加经常性处于饥饿状态胆固醇合成减少，类固醇合成减少）。2、直接影响中枢ACTH释放。即TH增加ACTH释放继而皮质酮释放增多。晚期减少的原因则和抗甲亢药物有关，或者垂体ACTH合成原料不足等原因。The data are interpreted to suggest 2 independent effects of thyroid hormone upon pituitary ACTH activity: 1) an indirect effect through its influence on the peripheral metabolism of cortisol mediated by the negative feedback mechanism on the magnitude of ACTH secretion, and 2) a direct effect on the central nervous system centers regulating ACTH release. The findings also offer an explanation for the contradictory assessments of pituitary ACTH reserve in patients with altered thyroid function previously reported in the literature. - See more at: http://press.endocrine.org/doi/abs/10.1210/jcem-25-1-20#sthash.pMYogZAM.dpuf

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决定20

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展开引用Teanie决定20书上没有相关说法，求解TH对垂体ACTH影响通过：1、通过影响外周皮质醇代谢间接影响ACTH释放（TH分泌增多患者BMI增加经常性处于饥饿状态胆固醇合成减少，类固醇合成减少）。2、直接影响中枢ACTH释放。即TH增加ACTH释放继而皮质酮释放增多。晚期减少的原因则和抗甲亢药物有关，或者垂体ACTH合成原料不足等原因。Thedataareinterpretedtosuggest2independenteffectsofthyroidhormoneuponpituitaryACTHactivity:1)anindirecteffectthroughitsinfluenceontheperipheralmetabolismofcortisolmediatedbythenegativefeedbackmechanismonthemagnitudeofACTHsecretion,and2)adirecteffectonthecentralnervoussystemcentersregulatingACTHrelease.ThefindingsalsoofferanexplanationforthecontrADIctoryassessmentsofpituitaryACTHreserveinpatientswithalteredthyroidfunctionpreviouslyreportedintheliterature.-Seemoreat:http://press.endocrine.org/doi/abs/10.1210/jcem-25-1-20#sthash.pMYogZAM.dpuf......非常感谢！

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jrwest

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1楼大神啊，膜拜

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