下载所得到的文件列表tolerogenicdendriticcellsthatinhibitautoimmunearthritiscanbeinducedbybinationofcarvacrolandthermalstress耐受性树突状细胞,抑制自身免疫性关节炎可以诱导香芹酚和热应力的组合.pdf
TolerogenicDendriticCellsThatInhibitAutoimmune
ArthritisCanBeInducedbybinationofCarvacrol
andThermalStress
RachelSpiering1,RuurdvanderZee1,JoseeWagenaar1,DimosKapetis2,FrancescaZolezzi2,Willemvan
Eden1,FemkeBroere1*
1DepartmentofInfectiousDiseasesandImmunology,UtrechtUniversity,Utrecht,herlands,2DepartmentofBiotechnologyandBioscience,Genopolis,University
ofMilano-a,Milan,Italy
Abstract
Tolerogenicdendriticcells(DCs)caninduceregulatoryTcellsanddampenpathogenicTcellresponses.Therefore,theyare
possibletherapeutictargetsinautoimmunediseases.InthisstudyweinvestigatedwhethermousetolerogenicDCsare
inducedbythephytonutrientcarvacrol,amoleculewithknownanti-inflammatoryproperties,binationwitha
physiologicalstress.WeshowthattreatmentofDCswithcarvacrolandthermalstressledtothemRNAexpressionofboth
pro-andanti-inflammatorymediators.Interestingly,treatedDCswiththismixedgeneexpressionprofilehadareduced
abilitytoactivatepro-inflammatoryTcells.Furthermore,theseDCsincreasedtheproportionofFoxP3+regulatoryTcells.In
vivo,prophylacticinjectionofcarvacrol-thermalstresstreatedDCspulsedwiththediseaseinducingantigenwasableto
suppressdiseaseinamousemodelofarthritis.ThesefindingssuggestthattreatmentofmousebonemarrowderivedDCs
withcarvacrolandthermalstressinduceafunctionallytolerogenicDCthatcansuppressautoimmunearthritis.Herewith
carvacrolseemstooffernovelopportunitiesforthedevelopmentofadietarybasedinterventioninchronicinflammatory
diseases.
Citation:SpieringR,vanderZeeR,WagenaarJ,KapetisD,ZolezziF,etal.(2012)TolerogenicDendriticCellsThatInhibitAutoimmuneArthritisCanBeInducedby
binationofCarvacrolandThermalStress.PLoSONE7(9):e46336.doi:10.1371/journal.pone.0046336
Editor:SongGuoZheng,UniversityofSouthernCalifornia,UnitedStatesofAmerica
ReceivedApril7,2012;AcceptedAugust31,2012;PublishedSeptember25,2012
Copyright:2012Spieringetal.Thisisanopen-accessarticledistributedunderthetermsofthemonsAttributionLicense,whichpermits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:InnovatiegerichteOnderzoeksprogramma(IOP)Genomics:IGE07004()EuropeanUnionFP7TOLERAGE:HEALTH-F4-
2008-20215(/)DutchArthritisAssociation(ormatie-voor-doelgroepen/professionals/research-funding).The
fundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript.
CompetingInterests:Theauthorshavedeclaredthatpetinginterestsexist.
*E-mail:f.******@uu.nl
Currentaddress:Singaporework(SIgN),Singapore,Singapore
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