

Thisproductisfreezedried.Allwatermoleculeshavebeenremoved.

Everylotistried&testedinarelevantBIOLOGicalassay.
OurBioassay
- Wu,W. etal. (2012) Neurosci.Lett. 506, 307.
- AlomoneLabsAmitriptylinehydrochlorideinhibitsL-typevoltage-gatedCa2+ currentsexpressedin Xenopus oocytes.A.TimecourseofCaV1.2/α2-δ1/β1currentinhibitionby800µM Amitriptyline hydrochloride(#A-155).Currentswereelicitedbyapplicationofvoltagerampsfromaholdingpotentialof-100mVto+50mV(100msec).B.Superimposedexampletracesofcurrentresponsesbeforeandduringperfusionof800µMAmitriptylinehydrochloride,asindicated.
- 1.Soldatov,N.M. (2012) ISRNMol.Biol. 2012,691341.
- 2.Haderer,A. etal. (2003) Anesth.Analg. 96, 1707.
- 3.Baldessarini,R.J. etal.(1995) ThePharmacologicalBasisofTherapeutics 431.
- 4.Bryson,H.M.and Wilde,M.I. (1996) DrugsAging 8, 459.
- 5.Zahradník,I. etal.(2008) J.Pharmacol.Exp.Ther. 324, 977.
Voltage-gatedL-typeCaV1.2calciumchannelscouplemembranedepolarizationtotransientincreaseincytoplasmicfreeCa2+concentrationthatinitiatesanumberofessentialcellularfunctionsincludingcardiacandvascularmusclecontraction,geneexpression,neuronalplasticity,andexocytosis1.
Tricyclicantidepressants(TCAs)areknowntoinhibitCa2+currents,includingtheL-typeCaV1.2channelinheartmyocyteandneurons2.Otherknownphysiologicaltargetsoftricyclicantidepressantsinthecentralnervoussystemarethe5-HT2serotoninreceptorsandtheα1-adrenergicreceptors3.
Amitriptylinehydrochloride,atricyclicantidepressant,isusedforanumberofmedicalconditionsincludingmanagementofdepressive,anxietyandbipolardisorders3andmanagementofchronicpainsuchasneuropathicpain,diabeticneuropathy,postherpeticneuralgiaandfibromyalgia4.
Theproposedmechanismsofactionforamitriptylinehydrochlorideincludeinhibitionofthereuptakeofserotoninandnorepinephrine,inhibitionofNMDAreceptors,ofvoltage-gatedionchannelssuchasCa2+andNa+channelsandinteractionwithadenosinereceptors5.
Amitriptylinehydrochloride(#A-155) isahighlypure,synthetic,andbiologicallyactivecompound.
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因此所有羊抗兔可以结合兔子的同种异型抗体,也就是说只要是兔子产生的抗体,羊抗兔(也叫抗抗体或者2抗)都可与之结合。
在试验中,二抗经常被做了手脚,打上了标记,比如辣根过氧化物酶,经常被用在ELISA,WESTERN等经典的生物学试验中。
Anti-HIF-1 Alpha抗体,缺氧诱导1α 抗体HIF-1α抗体种属:兔抗单克隆抗体鼠抗单克隆抗体抗体浓度1mg/ml
抗体相关标记:HRP,Biotin,Gold,RBITC,AP,FITC,Cy3,Cy5,Cy5.5,Cy7,PE,PE-Cy3,PE-Cy5,PE-Cy5.5,PE-Cy7,APC,Alexa Fluor 350,Alexa Fluor 488,Alexa Fluor 555,
Alexa Fluor 647
抗体交叉反应:鼠鼠鸡 狗猪羊牛兔等......
Anti-HIF-1 Alpha抗体,缺氧诱导1α 抗体HIF-1α抗体应用:用于做石蜡切片免疫组化冰冻切片免疫组化ElisaWB免疫荧光等实验

