
Product information | Protocols | References | Technical support | Reviews |
Product overview
Product name | Kynurenic acid polyclonal antibody |
Synonyms | Kinurenic acid polyclonal antibody 4-Hydroxyquinoline-2-carboxylic acid polyclonal antibodyKYNA polyclonal antibody |
Immunogen | Conjugated kynurenic acid |
Specificity | When tested in competitive ELISA, the anti-Kynurenic polyclonal antibody did not show any significant cross reactivity with Quinaldic and Xanthurenic conjugates. |
Lot number | 140401 |
Storage
Form | Liquid |
Purity | Purified anti-serum |
Storage | Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
Material safety datasheet | Download MSDS |
Protocols
Immunohistochemistry (IHC) | Dilute at 1:200-1:2000. Perform heat antigen retrieval (pH=6) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
Comments | Optimal working dilutions must be determined by the end-user |
Restrictions | For research use only |
References
Antibody not yet cited. Submit an article and get a 10% discount.
Selected articles on Kynurenic acid:
- Justinova Z et al. Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid. Nat Neurosci. 2013 Nov;16(11):1652-61. doi: 10.1038/nn.3540. Epub 2013 Oct 13.
- StoneTW, Stoy N, Darlington LG. An expanding range of targets for kynureninemetabolites of tryptophan. Trends Pharmacol Sci. 2013 Feb;34(2):136-43.doi: 10.1016/j.tips.2012.09.006. Epub 2012 Nov 1.
- Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci. 2012 Jul;13(7):465-77. doi: 10.1038/nrn3257.
- Moroni F, Cozzi A, Sili M, Mannaioni G. Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery. J Neural Transm. 2012 Feb;119(2):133-9. doi: 10.1007/s00702-011-0763-x. Epub 2012 Jan 4.
- Linderholm KR et al. Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia. Schizophr Bull. 2012 May;38(3):426-32. doi: 10.1093/schbul/sbq086. Epub 2010 Aug 20.
- Stone TW, Forrest CM, Darlington LG. Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection. FEBS J. 2012 Apr;279(8):1386-97. doi: 10.1111/j.1742-4658.2012.08487.x. Epub 2012 Mar 27.
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