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| ProductDetails | |
|---|---|
| Synonyms | CPSD;CTSD;EC=3.4.23.5 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | AF1C7 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-CathepsinDproteinpurifiedfromE.coli. |
| Application | WesternBlot(1:5,000) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
CathepsinD(CatD)isaubiquitouslyexpressedlysosomalaspartylproteaseinvolvedinthenormaldegradationofproteinsapoptosisandautophagy.HumanCatDissynthesizedontheendoplasmicreticulumasapre-pro-enzyme.PreprocathepsinD(412aa)iscleavedandglycosylatedtoformaninactiveprocathepsinD(392aa)andthenfurthercleavedtogenerateanactiveintermediate(348aa)single-chainmolecule.TheactiveintermediateisfurtherprocessedintomaturetwochainformofcathepsinD,thisprocessingstepiscarriedoutbycathepsinBorL.Thetwo-chainformconsistsofanaminoterminallightchainandacarboxyl-terminalheavychain.Additionally,severalmoreaminoacidsareremovedfromthecarboxylterminusoftheheavychain.ProcathepsinD(pCD),secretedfromcancercells,actsasamitogenonbothcancerandstromalcellsandstimulatestheirproinvasiveandpro-metastaticproperties.Acidproteaseactiveinintracellularproteinbreakdown.InvolvedinthepathogenesisofseveraldiseasessuchasbreastcancerandpossiblyAlzheimerdisease
ProductReferences
1)ZaidiNetal.,(2008)BiochemBiophysResCommun7;376(1):5-9.(General)
2)Liaudet-CoopmanEetal.,(2006)CancerLett237;167-179.(General)
2)Liaudet-CoopmanEetal.,(2006)CancerLett237;167-179.(General)
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发布于 : 2021-08-25
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