Overview:
Anti cdk2 antibody recognizes a protein encoded by a gene member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
References:
1. Elledge, S.J., et al.: A new human p34 protein kinase CDK2, identified by complementation of a cdc28 mutation, is a homolog of Xenopus Eg1. EMBO J. 1991: 10; 2653-2659. 2. Giordano, A., et al.: Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science. 1991: 253; 1271-1275. Tsai, L.H., et al.: Isolation of the human CDK2 gene that encodes the cyclin A and adenovirus E1A-associated p33 kinase. Nature.1991: 353; 174-177.
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