Overview:
Post-translational modification of proteins and peptides is a robust way to regulate function of existing proteins or peptides.Methylation on lysine residues is one example of post-translational modification and is performed by a variety of protein methyltransferases in the cell. C/EBPs are extensively modified by methylation of lysine side chains and this regulated methylation profoundly affects the activity of C/EBPs (1). The Methylated Lysine Antibody conjugated to HRP detects methylation on lysine residues in proteins and peptides.
References:
1. Leutz, R. et al: Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs. Transcr. 2011 Jan;2(1):3-8.
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