

This product is freeze dried. All water molecules have been removed.

Every lot is tried & tested in a relevant biological assay.
Our Bioassay
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- Waschk, D.E. et al. (2011) Am. J. Physiol. Cell. Physiol. 300, C843.
- Alomone Labs 1-EBIO activates KCa3.1 currents expressed in HEK 293T cells.A. Time course of KCa3.1 current amplitude and its activation by 50 µM 1-EBIO (#E-150). Currents were elicited by application of voltage ramp from -120 mV to +60 mV (150 msec), delivered every 10 seconds, holding potential of -80mV. B. Superimposed example traces of current responses before and during perfusion of 50 µM 1-EBIO as indicated.
- 1. Wong, R. et al. (2014) J. Neurosci. 34, 13371.
- 2. Coleman, N. et al. (2014) Mol. Pharmacol. 86, 342.
- 3. Strøbæk, D. et al. (2013) Br. J. Pharmacol. 168, 432.
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1-EBIO is a potent KCa2/3 channel activator that activates the channels by increasing the Ca2+ sensitivity by stabilizing the interaction between calmodulin and the channels1,2, thus shifting the activation curve of the channels to the left. 1-EBIO activates KCa3.1 with an EC50 value of around 30 μM and all three KCa2 channels with EC50 value around 300 μM2.
The Ca2+-activated K+ channel, KCa3.1, plays a major role in the controlled expression of essential genes that are responsible for several physiological processes including- membrane potential, cell volume proliferation, migration and production of inflammatory mediators by participating in the regulation of calcium entry. A highly regulated and sustained increase in cytosolic Ca2+ is critical in these processes making KCa3.1 a potential target for therapy of several disease1,3.
1-EBIO (#E-150) is a highly pure, synthetic, and biologically active compound.
ebiomall.com






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1.若都为正常,那么并未有太大问题,只要定期复查就可以了。
2.如果TGAb、TMAb、甲状腺功能均高,那么就是桥本氏甲状腺炎并甲亢,需要抗甲亢治疗。
3.如果TGAb、TMAb高,甲状腺功能下降,那么就是桥本氏甲状腺炎并甲减,需要进行甲减治疗。
4.如果TGAb、TMAb高,甲状腺功能正常,那么就是桥本氏甲状腺炎,无需特殊治疗,只要定期复查甲状腺功能就可能以了,不过这种情况有可能以后演变成甲减或者甲亢。
1.若都为正常,那么并未有太大问题,只要定期复查就可以了。
2.如果TGAb、TMAb、甲状腺功能均高,那么就是桥本氏甲状腺炎并甲亢,需要抗甲亢治疗。
3.如果TGAb、TMAb高,甲状腺功能下降,那么就是桥本氏甲状腺炎并甲减,需要进行甲减治疗。
4.如果TGAb、TMAb高,甲状腺功能正常,那么就是桥本氏甲状腺炎,无需特殊治疗,只要定期复查甲状腺功能就可能以了,不过这种情况有可能以后演变成甲减或者甲亢。
英文名称:horseradish peroxidase;HRP
定义:一种糖蛋白,由于在辣根中该酶的含量很高,故名。它以铁卟啉为辅基,在过氧化氢存在时能催化苯酚、苯胺及其取代物聚合。

