G6b is a t ype I transmembrane glycoprotein in the immunoglobul in superfamily that is encoded within the human class III major histocompatibility complex (1 ­ 3). It is expressed mainly on platelets, and has also been detected on megakaryocytes and the human cell line K562 (2 ­ 5). Crosslinking of G6b inhibits agonist­stimulated platelet aggregation and activation (5). The 241 amino acid (aa) human G6b isotype B (G6b­B) contains a 17 aa signal sequence, a 125 aa extracellular domain with one V­type Ig ­like domain and one N­linked glycosylation site, a 21 aa transmembrane sequence and a 78 aa cytoplasmic sequence with two ITIM inhibitory motifs and a SH3 bindingsite (1, 2). Phosphorylation at Y211 within the first ITIM is required for interaction with SHP adapt or/ tyrosine phosphatase proteins (2, 3). Of several described isoforms, all are identical within aa 22­136, which includes most of the extracellular domain. One contains an alternate signal sequence, while at least two lack a transmembrane sequence and are secreted (2). At least two others, including G6b­A, express alternate C­t ermini that lack the ITIM motifs. Of the known isoforms, G6b­A and G6b­B predominate in platelets. It is possible that G6b­A may be paired with and control inhibition by G6b­B (4). Heparin interacts with the G6b extracellular domain with high­affinity and may contribute to G6b activity or adhesion to extracellular matrix (6).||Source: Chinese Hamster Ovary cell line, CHO-derived Human G6b (Asn18 Gln142), Accession # O95866, IEGRMD, Human IgG1, (Pro100 Lys330).||Predicted Molecular Mass: 40.0kD (monomer) SDS-PAGE under reducing conditions.||Activity: Measured by its binding ability in a functional ELISA. When 1ug/ml of rhG6b/Fc is captured by a goat anti-human IgG Fc coated plate, the concentration of biotinylated heparin that produces 50% of the optimal binding response is found to be approximately 10-40ng/ml.||Endotoxin: ≤1.0 EU per 1 ug of the protein by the LAL method.||Applications:|Suitable for use in ELISA. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|12 months from date of receipt, 20 to 70°C as supplied.|1 month, 2 to 8°C under sterile conditions after reconstitution.| months, 20 to 70°C under sterile conditions after reconstitution.|Avoid repeated freeze thaw cycles.

USBIo全称United States BIOLOGical，位于麻省斯万普斯科特(Swampscott, MA)。全美**的抗原抗体和生化试剂供应商，目前向全球六十余个国家的科研工作者提供约50,000种抗体、抗原和生化试剂，以质量**闻名。主要产品种类包括：抗体、生化试剂、基因克隆相关产品、培养基、生长因子等细胞因子、分子生物学试剂。美国US Biological公司是生物化学和生物学试剂的专业生产商，产品服务于免疫学，分子生物学，分子遗传学，体外诊断，组织培养等科研领域。产品精确度高，质量稳定，产品数量巨大，提供70,000多种抗体、抗原和生化试剂等。

Usbio的生物化学品，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。USBio产品从经济实惠的研究数量到更大的批量可用于工艺开发和生产。我们的客户包括位于美国和国外的大多数*的制药和生物技术公司。

USbiological公司致力于以价值，诚信和真正的个人购买体验降低研究成本。USbiological的生物化学，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。产品可以从负担得起的研究数量到大批量用于工艺开发和生产。

USBio（UnitedStatesBiological，或简称USBiological）位于麻省斯万普斯科特(Swampscott,MA)。作为全美最大的抗原抗体和生化试剂供应商，USBiological目前向全球六十余个国家的科研工作者提供约150,000种抗体、抗原和生化试剂，以质量卓越闻名。主要产品种类包括：抗体、生化试剂、基因克隆相关产品、培养基、生长因子等细胞因子、分子生物学试剂。美国USBiological的产品服务于免疫学，分子生物学，分子遗传学，体外诊断，组织培养等科研领域。USBiological一直恪守“为您的研究减少成本”原则，提供高纯度、高品质的产品，并在大多数生化试剂、生物与培养基产品线上保持最高的性价比。USBiological的产品被广泛用于各种科学研究领域，包括基因组研究、生物技术、药物研发和疾病诊断等。USBiological的产品从小型科研级到生物制品大规模级规格均有提供。众多全球顶ji的生物制药和生物技术公司都在使用USBiological的高品质产品。

usbio的生化试剂，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。

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