| AMG 548P38α inhibitor,potent and selective |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
AMG 548 Dilution Calculator
calculate
AMG 548 Molarity Calculator
calculate
| Cas No. | 864249-60-5 | SDF | Download SDF |
| Chemical Name | (S)-2-((2-amino-3-phenylpropyl)amino)-3-methyl-5-(naphthalen-2-yl)-6-(pyridin-4-yl)pyrimidin-4(3H)-one | ||
| Canonical SMILES | O=C1N(C)C(NC[C@H](CC2=CC=CC=C2)N)=NC(C3=CC=NC=C3)=C1C4=CC=C5C(C=CC=C5)=C4 | ||
| Formula | C29H27N5O | M.Wt | 461.56 |
| Solubility | <49.8mg l="" in="" dmso;=""><49.8mg l="" in="" ethanol=""> | Storage | Store at -20°C |
| Physical Appearance | Yellow solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
AMG 548 is a potent and selective inhibitor of p38α with IC50 values of 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ, respectively.
P38 mitogen-activated protein kinase (p38) is a serine/threonine kinase and is responsive to a variety of cellular stresses including inflammatory cytokines, osmotic shock, ultraviolet light, lipopolysaccharides (LPS) and growth factors. P38α kinase involved in the biosynthesis of TNFα and IL-1β at the transcriptional and translational level [1][2].
AMG 548 is a potent and selective p38α inhibitor. In the antagonistic enzyme fragment complementation (EFC) and β-catenin-driven luciferase (SuperTOPflash) reporter gene assays, AMG 548 inhibited Wnt/β-catenin signaling, which was due to cross-reactivity with another kinase. AMG 548 inhibited 17 kinases by more than 80%. In U2OS-EFC cells, AMG 548 inhibited CKIδ and CKIε, which played an important role in the activation of Wnt/b-catenin signaling. Also, the concentration of AMG 548 needed to inhibit CKIδ/ε in cells was closely approximate that required to inhibit Wnt/b-catenin signaling in the EFC and TOPflash assays, which suggested AMG 548 inhibited Wnt/b-catenin signaling mediated by the inhibition of CKIδ/ε [3].
References:[1]. Dominguez C, Powers DA, Tamayo N. p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discov Devel, 2005, 8(4): 421-430.[2]. Lee MR, Dominguez C. MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein. Curr Med Chem, 2005, 12(25): 2979-2994.[3]. Verkaar F, van der Doelen AA, Smits JF, et al. Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ. Chem Biol, 2011, 18(4): 485-494.
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
纯水机，跟净水机或者净水器的区别是需要用电(大多数)，有一个真空储水罐，纯水机包含了净水机或者净水器的功能和使用材质，过滤更高可达到万分之一微米，因为最重要的是它采用了RO反渗透技术，因为过滤更精细，所以一般的水压是不能顺畅通过的，所以需要用电，电要带动机器本身佩戴的增压泵来给原水打压才能通过。
事实上很多细菌病毒异色异味也只有纯水机能完全的过滤掉。
这只是一些最基本的常识。希望对楼主有帮助吧，本人专业从事净水行业多年，也可以看本人以往的知道回答！
纯水机的价格影响因素除了进口品牌和国产品牌的差异外，主要取决于产量、用途以及其他特殊要求。
综合来看，除非有硬性规定或者需要采用进口品牌来提升实验室形象，否则建议选择国产品牌即可，因为实际上纯水机作为实验室常规设备，在工艺技术上知名度较高的国产品牌已足与进口相媲美，且价格仅为进口的1/3左右。
你需要先确定采购水机的主要实验用途，不同的实验用途，对水的要求是不一样的，从而也决定了所采购纯水机的配置，进而决定价格。
水中需纯化的物质主要有：无机离子、总有机碳（TOC）、微小粒子、微生物（内毒素、热原）、弱电解质。根据对以上物质的去除度，生产出来的纯水分为三个级别：初级纯水、中级水、超纯水。一般来水，仅产初级产水的纯水机价格在1.2万左右（产量10L）；同时产初级纯水和超纯水的纯水机价格在（2-3万左右，产量10L）。
此外，还需要确定具体的实验用途，不同的实验用水，对于水中的物质去除度是有区分的，会有一定的倾斜度，比如细胞培养型实验，就对无机离子和TOC去除度要求严格；无机分析实验的话对无机离子去除要求高。
国产中，锐思捷、力康都还不错。
有些同行用娃哈哈，能满足药典吗？纯水机呢？
五大过滤功效：去除异色、异味、重金属、杜绝细菌、根除水碱。
超滤净水机过滤精度达0.01微米，它具有更高的强度，更好的安全性能以及更大的水通量等特性。四大过滤功效：去除异色、异味、重金属、杜绝细菌
纯水机，是利用反渗透膜产出纯净水的净水机，属于直饮机。
二者区别：直饮机是一个统称，包含纯水机、超滤直饮机等；纯水机就是生产纯净水的机器，出水可以直接饮用。
