| ATB-343hybrid molecule of an H2S donor and the NSAID indomethacin |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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| Cas No. | 1000700-26-4 | SDF | Download SDF |
| Chemical Name | 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester-1H-indole-3-acetic acid | ||
| Canonical SMILES | COc1ccc2c(c1)c(CC(=O)Oc1ccc(cc1)c1ssc(=S)c1)c(C)n2C(=O)c1ccc(Cl)cc1 | ||
| Formula | C28H20ClNO4S3 | M.Wt | 566.1 |
| Solubility | ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
ATB-343, also named as indomethacin, is an H2S-releasing derivative of indomethacin [1].
Hydrogen sulfide (H2S) is a newly recognized signaling molecule with potent cytoprotective actions. Hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. Hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation [2].
In vitro: Indomethacin enhanced the NK cell activity in vitro by blocking the prostaglandin production of monocytes [3].
In vivo: In rats, oral administration of ATB-343 significantly inhibited gastric prostaglandin synthesis and systemic COX-1 activity [1]. Indomethacin was a potent inhibitor of prostaglandin synthesis. Indomethacin suppressed in vivo thyroid hormone secretion and cholera toxin-induced intestinal fluid accumulation. Indomethacin in submicromolar concentrations inhibited cyclic AMP-dependent protein kinase and endogenous protein phosphorylation [4].
Clinical trials: Indomethacin has entered clinical trial in Alzheimer"s disease [5].
References:[1] Wallace J L. Hydrogen sulfide-releasing anti-inflammatory drugs[J]. Trends in Pharmacological Sciences, 2007, 28(10): 501-505.[2] Wallace J L. Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract[J]. Antioxidants & redox signaling, 2010, 12(9): 1125-1133.[3] Pedersen B K, Oxholm P, Klarlund K. Characterization of the in vivo and in vitro effects of indomethacin on human natural killer cell activity[J]. Allergy, 1986, 41(7): 532-536.[4] Kantor H S, Hampton M. Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase[J]. 1978.[5] Rogers J, Kirby L C, Hempelman S R, et al. Clinical trial of indomethacin in Alzheimer"s disease[J]. Neurology, 1993, 43(8): 1609-1609.
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请回答明确,谢谢
装置是这样的:旋转蒸发仪上的冷凝管的水直接流到真空泵里以冷却真空泵然后再从真空泵里流出来.
现在的问题是,我第一天清洗过真空泵之后,第二天再用就发现真空泵里的水已经有股臭味了,有没有什么好的办法可以让它不臭?这样每天都处理的话,太浪费时间了.如果哪位有什么好主意的话,请告知,谢谢!
要看清楚每个真空泵的真空度，选择使用。有必要时，自己测定一下其真空度，若与所写数值有差别时，请告知管理员。
使用时记得加冷阱，有必要时请对所蒸产品进行预处理。
使用结束后，先停止加入，并等体系冷却至室温，再放气，关泵，撤掉冷阱，千万不要弄反顺序。
如发现真空泵管道漏气时，请及时与管理员联系。
若是由于个人操作失误，导致真空泵损坏时，管理员有权停其使用权限，并让其负责维修。
本规定自贴出起生效，请大家遵守以上规定。
