Description
A-779isaninhibitoroftheMasreceptor.Onitsown,A-779hasnoBIOLOGicalactivity;however,throughbindingtheMasreceptor,itinhibitsangiotensin(1-7)signaling(preventingvasodilationandinsulinsensitization)andinhibitssomedownstreaminsulinsignaling.
References
TaoX,FanJ,KaoG,etal.Angiotensin-(1-7)attenuatesangiotensinII-inducedsignalingassociatedwithactivationofatyrosinephosphataseinSprague-Dawleyratscardiacfibroblasts.BiolCell.2014Mar18.[Epubaheadofprint].PMID:24641355.
SantosRA,Campagnole-SantosMJ,BarachoNC,etal.CharacterizationofanewangiotensinantagoNISTselectiveforangiotensin-(1-7):evidencethattheactionsofangiotensin-(1-7)aremediatedbyspecificangiotensinreceptors.BrainResBull.1994;35(4):293-8.PMID:7850477.