BiologicalActivity
PotentandselectiveBRPFbromodomaininhibitor(Kdvaluesare31,108and408nM,forBRPF1B,2and3,respectively.Exhibits>32-foldselectivityforBRPFsoverBRD9andothernon-ClassIVbromodomains.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheNI57probesummaryontheSGCwebsite.
CompoundLibraries
NI57isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 383.42 |
| Formula | C19H17N3O4S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 91827373 |
| InChIKey | UEMQPCYDWCSVCU-UHFFFAOYSA-N |
| Smiles | O=S(NC1=CC=C(N(C)C(C(C)=C2)=O)C2=C1)(C3=C(OC)C=C(C#N)C=C3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.34 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight383.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.61mL | 13.04mL | 26.08mL |
| 5mM | 0.52mL | 2.61mL | 5.22mL |
| 10mM | 0.26mL | 1.3mL | 2.61mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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