美国Tocris公司 Tocris多肽,Tocris/OF 1/5289/10/10 mg,多肽,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/OF 1/5289/10/10 mg

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Tocris

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5289/10

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4000-520-616

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Description:SelectiveBRPF1BandBRPF2inhibitor

ChemicalName:4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveBRPF1BandBRPF2bromodomaininhibitor(K_dvaluesare100and500nMrespectively).Exhibits39-foldselectivityforBRPF1BandBRPF2overBRD4.AcceleratesFRAPrecoveryat5μMinaBRPF2FRAPassay.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheOF1probesummaryontheSGCwebsite.

CompoundLibraries

OF1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	440.31
Formula	C₁₇H₁₈BrN₃O₄S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	919973-83-4
PubChemID	35397514
InChIKey	YUNQZQREIHWDQT-UHFFFAOYSA-N
Smiles	CN1C2=C(C=C(OC)C(NS(C3=C(C)C=C(Br)C=C3)(=O)=O)=C2)N(C)C1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	8.81	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight440.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.27mL	11.36mL	22.71mL
5mM	0.45mL	2.27mL	4.54mL
10mM	0.23mL	1.14mL	2.27mL
50mM	0.05mL	0.23mL	0.45mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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