BiologicalActivity
Selective,Hsp90competitiveinhibitor(Ki=1.7nM).DisplaysnosignificantactivityatarangeofATP-bindingkinasesorNa+K+ATPase.InducesdegradationofHER-2invitro(EC50=38nMinMCF-7cells).Inhibitsgrowthandpromotescelldeathinavarietyofhumantumorcells.Orallybioavailable.
CompoundLibraries
BIIB021isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 318.76 |
| Formula | C14H15ClN6O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 848695-25-0 |
| PubChemID | 16736529 |
| InChIKey | QULDDKSCVCJTPV-UHFFFAOYSA-N |
| Smiles | ClC1=C2C(N(CC3=NC=C(C)C(OC)=C3C)C=N2)=NC(N)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.88 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight318.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.14mL | 15.69mL | 31.37mL |
| 5mM | 0.63mL | 3.14mL | 6.27mL |
| 10mM | 0.31mL | 1.57mL | 3.14mL |
| 50mM | 0.06mL | 0.31mL | 0.63mL |
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