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Description:cGMPanalog;activatesPKG
ChemicalName:8-Bromoguanosinecyclic3',5'-monophosphatesodiumsalt
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
MembranepermeablecGMPanalogthatactivatesproteinkinaseG(PKG).4.3-foldmorepotentthancGMPinactivatingPKG1αandpromotesrelaxationoftrachealandvascularsmoothmuscletissueinvitro.
TechnicalData
| M.Wt | 446.09 |
| Formula | C10H10BrN5NaO7P |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 51116-01-9 |
| PubChemID | 23702959 |
| InChIKey | ZJRFCXHKYQVNFK-YEOHUATISA-M |
| Smiles | [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1NC(N)=NC2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.61 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight446.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.24mL | 11.21mL | 22.42mL |
| 5mM | 0.45mL | 2.24mL | 4.48mL |
| 10mM | 0.22mL | 1.12mL | 2.24mL |
| 50mM | 0.04mL | 0.22mL | 0.45mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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