BiologicalActivity
Water-solubleanalogof17-AAG(Cat.No.1515)andgeldanamycin(Cat.No.1368).BindstheATPbindingsiteofHsp90andinhibitsitschaperoneactivity.Displaysmorepotentantitumoractivitythan17-AAG(meanGI50valuesare53and123nMfor17-DMAGand17-AAGrespectively).
LicensingInformation
SoldwiththepermissionoftheNIH,USPatent6,890,917
TechnicalData
| M.Wt | 653.21 |
| Formula | C32H48N4O8.HCl |
| Storage | Desiccateat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 467214-21-7 |
| PubChemID | 9852573 |
| InChIKey | DFSYBWLNYPEFJK-IHLRWNDRSA-N |
| Smiles | O=C1C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.6 | 30 | |
| ethanol | 6.53 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight653.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.53mL | 7.65mL | 15.31mL |
| 5mM | 0.31mL | 1.53mL | 3.06mL |
| 10mM | 0.15mL | 0.77mL | 1.53mL |
| 50mM | 0.03mL | 0.15mL | 0.31mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。