Tocris试剂产品信息 Tocris Bioscience现货代理,Tocris/Gedunin/3387/1/1 mg,白蛋白,天然蛋白,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Gedunin/3387/1/1 mg

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Tocris

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3387/1

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Description:Hsp90inhibitor;exhibitsanticancerandantimalarialactivity

ChemicalName:(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

NaturallyoccurringHsp90inhibitor.InducesHsp90-dependentclientproteindegradationanddisplaysantiproliferativeactivityinvitro(IC₅₀valuesare3.22,8.84and16.8μMinSKBr3,MCF-7andCaCo-2cancercelllinesrespectively).Decreasesovariancancercellproliferationinvitroandmayenhancecisplatin-inducedreductioninproliferation(CAT.No3387).AlsoexhibitsantimalarialactivityagainstP.falciparum(IC₅₀valuesare0.14and3.1μMinparasitedevelopmentand[³H]-hypoxanthineuptakeassaysrespectively).

TechnicalData

M.Wt	482.57
Formula	C₂₈H₃₄O₇
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	2753-30-2
PubChemID	12004512
InChIKey	YJXDGWUNRYLINJ-BHAPSIHVSA-N
Smiles	O=C4[C@@H]6[C@]3(O6)[C@]2(C)[C@H](OC(C)=O)C[C@@]1([H])C(C)(C)C(C=C[C@@](C)1[C@]([H])2CC[C@](C)3[C@H]([C@]5=COC=C5)O4)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	48.26	100
	ethanol	4.83	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight482.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.07mL	10.36mL	20.72mL
5mM	0.41mL	2.07mL	4.14mL
10mM	0.21mL	1.04mL	2.07mL
50mM	0.04mL	0.21mL	0.41mL

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BiologicalActivity

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