TocrisX中国代理价格，厂家 Tocris离子通道调控剂,Tocris/PU H71/3104/10/10 mg,白蛋白,天然蛋白,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PU H71/3104/10/10 mg

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Tocris

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3104/10

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4000-520-616

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Description:PotentHsp90inhibitor

ChemicalName:6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofheatshockprotein90(Hsp90)(IC₅₀=51nMinMDA-MB-468cells).Alsoinhibitscellgrowthinarangeofbreastcancercelllines(IC₅₀valuesare17,31,65,87and140nMforSKBr3,MCF-7,MDA-MB-468,HCC-1806andMDA-MB-231cellsrespectively).Showntoinhibitcellproliferationandinduceapoptosisintriple-negativebreastcancer(TNBC)cells.

TechnicalData

M.Wt	512.37
Formula	C₁₈H₂₁IN₆O₂S
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	873436-91-0
PubChemID	9549213
InChIKey	SUPVGFZUWFMATN-UHFFFAOYSA-N
Smiles	IC1=CC4=C(OCO4)C=C1SC3=NC2=C(N)N=CN=C2N3CCCNC(C)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	51.24	100
	DMSO	51.24	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight512.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.95mL	9.76mL	19.52mL
5mM	0.39mL	1.95mL	3.9mL
10mM	0.2mL	0.98mL	1.95mL
50mM	0.04mL	0.2mL	0.39mL

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