Tocris GPCR ligands Tocris配体,Tocris/Radicicol/1589/1/1 mg,白蛋白,天然蛋白,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Radicicol/1589/1/1 mg

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Tocris

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1589/1

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4000-520-616

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Description:Hsp90inhibitor.Antifungalantibiotic

ChemicalName:(1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antifungalantibiotic.Inhibitsheatshockprotein90(Hsp90)activitybybindingtotheATP-bindingpocket,subsequentlysuppressingcelltransformationinducedbysrc,rasandmos.Repressesestrogenreceptortranscriptionalactivityandinhibitsangiogenesis.

TechnicalData

M.Wt	364.78
Formula	C₁₈H₁₇ClO₆
Storage	Desiccateat-20°C
Purity	≥98%(HPLC)
CASNumber	12772-57-5
PubChemID	6323491
InChIKey	WYZWZEOGROVVHK-GTMNPGAYSA-N
Smiles	O=C2/C=C/C=C[C@@H](O3)[C@H]3C[C@@H](C)OC(C1=C(O)C=C(O)C(Cl)=C1C2)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	ethanol	9.12	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight364.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.74mL	13.71mL	27.41mL
5mM	0.55mL	2.74mL	5.48mL
10mM	0.27mL	1.37mL	2.74mL
50mM	0.05mL	0.27mL	0.55mL

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