BiologicalActivity
Inhibitorofheatshockprotein90(Hsp90)chaperoneactivity,andananalogofgeldanamycin(Cat.No.1368).Subsequentlyinhibitstheactivityofoncogenicproteinssuchasp185erbB-2(IC50=31nM),N-ras,Ki-rasandc-Akt.Antitumorinvivo.AlsoprotectsneuroProgenitorcellsagainststress-inducedapoptosisatlowconcentrations(10nM)invitro.
TechnicalData
| M.Wt | 585.7 |
| Formula | C31H43N3O8 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 75747-14-7 |
| PubChemID | 6440175 |
| InChIKey | AYUNIORJHRXIBJ-HTLBVUBBSA-N |
| Smiles | O=C1C(NCC=C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.57 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight585.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.71mL | 8.54mL | 17.07mL |
| 5mM | 0.34mL | 1.71mL | 3.41mL |
| 10mM | 0.17mL | 0.85mL | 1.71mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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