Overview:
Ubiquitin carboxyl-terminal hydrolase 25 (USP25) belongs to the ubiquitin-specific proteases (USPs) family, and removes conjugated ubiquitin from substrates (1). USP25 processes, recycles ubiquitin to prevent the proteasomal degradation of proteins (1). It modifies tetraubiquitin chains via hydrolysing ‘Lys-63’ linked polyubiquitins to negatively regulate the inflammation mediated by IL-17 (2). A genome-wide association study of inflammatory bowel disease (IBD) identified the SNPs at USP25 sites (3).
Gene Aliases:
USP21
Genbank Number:
NM_013396
References:
1. Valero R, et al. USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405.2. Zhong B, et al. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat Immunol. 2012 Nov; 13(11):1110-7. 3. Brant SR, et al. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 Jan; 152 (1):206-217.
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IgM是免疫球蛋白M(Immunoglobulin M,IgM)的缩写。根据结构的不同将免疫球蛋白分为五种,IgM是人的免疫球蛋白之一,其他还有lgA、lgG、IgD和lgE。
HSV1型导致的一般都是腰部以上的感染,典型症状是水泡有可能引起脑炎,而且有非活化状态的潜伏。所以我觉得你根本就不用担心这个抗体IgG阳性的化验单。
2-IgM也是一种特异性感染指标,但在人体内持续时间不长(有时是30天更短),往往是传染病的近期感染指标。呈阴性是指:你近期没有感染过结核杆菌。
文章原文链接http://www.jbc.org/content/282/23/16776.long

