IgG is a plasma-cell protein that is produced within the lymph nodes, spleen, bone marrow, thymus, small intestinal mucosa, respiratory tract mucosa, and other tissues. It is the only immunoglobulin that can cross the placenta. Since IgG is produced as part of the body"s response to bacteria, viruses, drugs, and tissue antigens, measurement of blood IgG levels can reveal hyper-responsiveness to antigen stimulation or physiological anomalies at IgG-producing sites, among other disorders. Thus, human IgG levels are often measured during allergy and immune response testing. The presence of high IgG levels has been linked to polyclonal hypergammaglobulinemia, collagen disease, asymptomatic M-proteinemia, chronic infection, myeloma, IgG multiple myeloma, and other pathological conditions. Low IgG levels, on the other hand, have been correlated with disorders such as agammaglobulinemia, hypogammaglobulinemia, severe immunodeficiency, and nephrosis syndrome.
IgG is a plasma-cell protein that is produced within the lymph nodes, spleen, bone marrow, thymus, small intestinal mucosa, respiratory tract mucosa, and other tissues. It is the only immunoglobulin that can cross the placenta. Since IgG is produced as part of the body"s response to bacteria, viruses, drugs, and tissue antigens, measurement of blood IgG levels can reveal hyper-responsiveness to antigen stimulation or physiological anomalies at IgG-producing sites, among other disorders. Thus, human IgG levels are often measured during allergy and immune response testing. The presence of high IgG levels has been linked to polyclonal hypergammaglobulinemia, collagen disease, asymptomatic M-proteinemia, chronic infection, myeloma, IgG multiple myeloma, and other pathological conditions. Low IgG levels, on the other hand, have been correlated with disorders such as agammaglobulinemia, hypogammaglobulinemia, severe immunodeficiency and nephrosis syndrome.
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ELISAs for IgG detection
The Human IgG EIA Kit is a colorimetric enzyme-linked immunosorbant assay (ELISA) for quantitative determination of human IgG in human blood and body-fluid samples. IgG is produced by activated B lymphocytes (plasma cells) and functions in many roles including immunity, infection, and opsonization.
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IgM是免疫球蛋白M(Immunoglobulin M，IgM)的缩写。根据结构的不同将免疫球蛋白分为五种，IgM是人的免疫球蛋白之一，其他还有lgA、lgG、IgD和lgE。
HSV1型导致的一般都是腰部以上的感染，典型症状是水泡有可能引起脑炎，而且有非活化状态的潜伏。所以我觉得你根本就不用担心这个抗体IgG阳性的化验单。
2-IgM也是一种特异性感染指标，但在人体内持续时间不长（有时是30天更短），往往是传染病的近期感染指标。呈阴性是指：你近期没有感染过结核杆菌。
文章原文链接http://www.jbc.org/content/282/23/16776.long
