BiologicalActivity
Cdc42GTPaseinhibitor(IC50=2μM).ReducesactivelevelsofCdc42inagedhematopoieticstemcells(HSCs)tothatinyoungHSCs.Reversestheaging-relatedandpolarityphenotypeofagedHSCstothatofyoungHSCsinvivo.IncreaseshistoneH4K16acetylationinagedHSCs.
CompoundLibraries
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TechnicalData
| M.Wt | 306.4 |
| Formula | C20H22N2O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 425399-05-9 |
| PubChemID | 2882155 |
| InChIKey | RXIUMAOXORBRCY-UHFFFAOYSA-N |
| Smiles | OCCNC1C2=C(C(C=C(C4=CC=CC=C4)C=C3)=C3N2)CCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.64 | 100 | |
| ethanol | 15.32 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight306.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.26mL | 16.32mL | 32.64mL |
| 5mM | 0.65mL | 3.26mL | 6.53mL |
| 10mM | 0.33mL | 1.63mL | 3.26mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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