BiologicalActivity
InhibitorofRacfamilyGTPases.BlocksactivationbydirectbindingtoRac1,Rac1b,Rac2andRac3(KDvaluesare40,50,60and250nMrespectively).InhibitsRac,RasandTiam-inducedgrowthtransformationofNIH-3T3fibroblasts.Reducesβ-amyloidpeptideproductioninvivo.
LicensingInformation
SoldforresearchuseonlyunderlicensefromExonHitTherapeuticsS.A.
TechnicalData
| M.Wt | 581.47 |
| Formula | C25H27F3N2O4S.2HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 754240-09-0 |
| PubChemID | 9938202 |
| InChIKey | LSECOAJFCKFQJG-UHFFFAOYSA-N |
| Smiles | O=C1C=C(CN4CCOCC4)OC=C1OCCCCCSC3=CC=NC2=CC(C(F)(F)F)=CC=C23.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.61 | 75 | |
| water | 58.15 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight581.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.72mL | 8.6mL | 17.2mL |
| 5mM | 0.34mL | 1.72mL | 3.44mL |
| 10mM | 0.17mL | 0.86mL | 1.72mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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