BiologicalActivity
Activatorofaldehydedehydrogenase2(ALDH2).Increasesactivityofwild-typeALDH2*1andvariantALDH2*2(by~2-foldand11-foldrespectively).CapableofpartlyrestoringmutantALDH2*2activity;protectiveagainstcardiacischemia.
CompoundLibraries
Alda1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 324.16 |
| Formula | C15H11Cl2NO3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 349438-38-6 |
| PubChemID | 831629 |
| InChIKey | NMKJFZCBCIUYHI-UHFFFAOYSA-N |
| Smiles | O=C(C3=C(Cl)C=CC=C3Cl)NCC1=CC(OCO2)=C2C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.42 | 100 | |
| ethanol | 3.24 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight324.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.08mL | 15.42mL | 30.85mL |
| 5mM | 0.62mL | 3.08mL | 6.17mL |
| 10mM | 0.31mL | 1.54mL | 3.08mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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