BiologicalActivity
DNAmethyltransferaseinhibitor.IncorporatesintoDNAformingcovalentadductswithcellularDNMT1,depletingenzymeactivity.Inducesdemethylationandreactivationofsilencedgenes.Improvestheefficiencyofreprogrammingofstemcells;inducesdifferentiationofmesenchymalstemcellsintocardiomyocytes.
CompoundLibraries
5-AzacytidineisalsoofferedaspartoftheTocriscreenPlus,TocriscreenEpigeneticsToolbox,TocriscreenLibraryofFDA-ApprovedCompoundsandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 244.2 |
| Formula | C8H12N4O5 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 320-67-2 |
| PubChemID | 9444 |
| InChIKey | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
| Smiles | O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(N=C(N)N=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.42 | 100 | |
| water | 12.21 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight244.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.1mL | 20.48mL | 40.95mL |
| 5mM | 0.82mL | 4.1mL | 8.19mL |
| 10mM | 0.41mL | 2.05mL | 4.1mL |
| 50mM | 0.08mL | 0.41mL | 0.82mL |
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