Overview:
SGK1isamemberoftheserum-andglucocorticoid-inducedproteinkinasethatisactivatedinvitroby3-phosphoinositide-dependentproteinkinase-1(PDK1)andinvivoinresponsetosignalsthatactivatephosphatidylinositol(PI)3-kinase(1).SGK1mRNAisexpressedinalltissuesandthelevelofSGK1mRNAisincreasedbystimulationwithserumordexamethasone.SGK1promotescellsurvivalbyphosphorylatingandinactivatingFKHRL1(2).SGKandAktdisplaydifferenceswithrespecttotheefficacywithwhichtheyphosphorylatethethreeregulatorysitesonFKHRL1.
GeneAliases:
SGK
GenbankNumber:
NM_005627
References:
1.Kobayashii,T.etal:Characterizationofthestructureandregulationoftwonovelisoformsofserum-andglucocorticoid-inducedproteinkinase.BiochemJ.1999Nov15;344Pt1:189-97.2.Brunet,A.etal:ProteinkinaseSGKmediatessurvivalsignalsbyphosphorylatingtheforkheadtranscriptionfactorFKHRL1(FOXO3a).MolCellBiol.2001Feb;21(3):952-65.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

