Overview:
STK19isamemberoftheserine/threoninekinasefamilythatshowsamanganese-dependentproteinkinaseactivityandphosphorylatesα-caseinatser/thrresiduesandhistoneatserresidues.STK19containsapositivelychargedputativenuclearlocalizationsignal,multiplepotentialphosphorylationsites,2amidationsites,9potentialN-myristoylationsites,andnoN-glycosylationsites.STK19hasbeenshowntolocalizepredominantlyinthenucleus(1).ThephosphorylationofSTK19isthoughttobeinvolvedintranscriptionalregulation.STK19localizestothemajorhistocompatibilitycomplex(MHC)classIIIregiononchromosome6(2).
GeneAliases:
D6S60;D6S60E;G11;HLA-RP1;RP1
GenbankNumber:
NM_004197
References:
1.Gomez-Escobar,N.et.al:TheG11genelocatedinthemajorhistocompatibilitycomplexencodesanovelnuclearserine/threonineproteinkinase.J.Biol.Chem.273:30954-30960,1998.2.Shen,L.et.al:StructureandgeneticsofthepartiallyduplicatedgeneRPlocatedimmediatelyupstreamofthecomplementC4AandtheC4BgenesintheHLAclassIIIregion:molecularcloning,exon-intronstructure,compositeretroposon,andbreakpointgeneduplication.J.Biol.Chem.269:8466-8476,1994.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

