Overview:
SRPK2isamemberoftheserine/arginine(SR)protein-specifickinasefamilythatarecellcycle-regulatedproteinkinaseswhichphosphorylateSRdomain-containingproteinsinnuclearspecklesandmediatethepre-mRNAsplicingevents(1).SRPK2knockdownresultsinhypophosphorylationoftheserine/argininedomain-containinghumanPRP28proteintherebydestABIlizingPRP28associationwiththetri-snRNP.RNAi-mediateddepletioninHeLacellsshowedthatSRPK2isessentialforcellviability,anditisrequiredforspliceosomalBcomplexformation(2).
GeneAliases:
SFRSK2,FLJ36101
GenbankNumber:
NM_182691
References:
1.Wang,H.Y.Etal;SRPK2:adifferentiallyexpressedSRprotein-specifickinaseinvolvedinmediatingtheinteractionandlocalizationofpre-mRNAsplicingfactorsinmammaliancells.J.CellBiol.140:737-750,1998.2.Mathew,R.etal:PhosphorylationofhumanPRP28bySRPK2isrequiredforintegrationoftheU4/U6-U5tri-snRNPintothespliceosome.NatStructMolBiol.2008May;15(5):435-43.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

