Overview:
SMYD2(alsoknownasSETandMYNDdomain-containingprotein2)isamemberoftheSMYDfamilyofproteinmethyltransferases.SMYD2isalsoknownaslysinemethyltransferaseprotein3C(KMT3C).SMYD2functionstorepresstranscriptionbyinteractingwiththeSin3AhistonedeacetylasecomplexandperformsmethylationofLys36inhistoneH3(1).TheexogenousexpressionofSMYD2inmousefibroblastsdecreasescellgrowth.SMYD2alsofunctionasaputativeoncogenebymethylatingp53andrepressingitstumorsuppressivefunction(2).
GeneAliases:
KMT3C;HSKM-B;ZMYND14
GenbankNumber:
BC049367
References:
1.Brown,M.A.et.al:IdentificationandcharacterizationofSmyd2:asplitSET/MYNDdomain-containinghistoneH3lysine36-specificmethyltransferasethatinteractswiththeSin3histonedeacetylasecomplex.Molec.Cancer5:26,2006.2.Huang,J.et.al:Repressionofp53activitybySmyd2-mediatedmethylation.Nature444:629-632,2006.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

