Overview:
Histone-lysineN-methyltransferase,Suppressorofvariegation4-20homolog1SUV420H1specificallytrimethylates"Lys-20"ofhistoneH4,whichinturnactsasaspecifictagforepigenetictranscriptionalrepression.Locatedinpericentricheterochromatinregions,andplaysacentralroleintheestablishmentofconstitutiveheterochromatinintheseregions.Interactswithafamilyofproteinsthatdisplaysimilaritywithdual-specificityphosphatases(dsPTPases)mediatedbyitsSETdomains.
GeneAliases:
KMT5B,CGI-85,MGC21161,MGC703
GenbankNumber:
BC103498
References:
1.TryndyakVP,etal:LossofDNAmethylationandhistoneH4lysine20trimethylationinhumanbreastcancercellsisassociatedwithaberrantexpressionofDNAmethyl-transferase1,Suv4-20h2histonemethyltransferaseandmethyl-bindingproteins.CancerBiolTher.5(1):65-70,2006.2.LaiCH,etal:IdentificationofnovelhumangenesevolutionarilyconservedinCaenorhaBDitiselegansbycomparativeproteomics.GenomeRes.10(5):703-13,2000.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

