Overview:
SENP1(SUMO-specificprotease1)isaproteasefromthede-SUMOylationproteasesuperfamilyandcatalyzesthematurationofSUMOprotein(smallubiquitin-relatedmodifier).Itplaysaroleintheregulationofandrogenreceptor-dependenttranscriptionandhypoxiasignaling(1).OverexpressionofSENP1wasfoundinprecancerousprostateintraepithelialneoplasialesionsandprostatecancertissuesamples,indicatingtheenzymemaypromoteprostatecancermetastasisandprogression(2).
GeneAliases:
SuPr-2
GenbankNumber:
NM_001267594
References:
1.Wenrong,X.etal:InhibitionofSUMO-specificprotease1inducesapoptosisofastrogliomacellsbyregulatingNF-κB/Aktpathways.ElsevierBV595(2):175-179,20162.Wang,Q.etal:SUMO-specificprotease1promotesprostatecancerprogressionandmetastasis.Oncogene32(19):2493-8,2013.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

