Overview:
Sentrin-specificprotease2(SENP2)isaproteasethatcatalyzesthehydrolysisofanalpha-linkedpeptidebondofthesmallubiquitin-likemodifier(SUMO)propeptidesleADIngtothematureformoftheproteinsandthedeconjugationofSUMO1,SUMO2andSUMO3fromtargetedprotein.SENP2playsaroleintheformationofadipocytesbydesumolyatingandpromotingCEPBPstABIlization(1).SENP2alsobindstoNup153,anucleoporinthatisconfinedtothenucleoplasmicfaceoftheporeandlocalizationofSENP2totheporemayspatiallyrestricttheactivityofthisenzyme(2).
GeneAliases:
KIAA1331,SMT3IP2,AXAM2
GenbankNumber:
NM_021627
References:
1.Chung,S.S.etal:ControlofAdipogenesisbytheSUMO-specificproteaseSENP2.Mol.Cell.Biol.30:2135-2146,2010.2.Hang,J.&Dasso,M:AssociationofthehumanSUMO-1proteaseSENP2withthenuclearpore.J.Biol.Chem.277(22):19961–6,2002.
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

