Overview:
AmemberoftheCXCchemokinefamily,CXCL12isstronglychemotacticforT-,B-,andcancercells.KnowntoexertitseffectsmainlythroughbindingtotheCXCR4receptor,CXCL12playsanimportantroleinmorphogenesis,angiogenesis,andcancermetastasis.CXCL12alsobindstoatypicalchemokinereceptorACKR3,whichactivatesthebeta-arrestinpathwayandactsasascavengerreceptorforCXCL12.Encodedbyasinglegene,SDF-1alpha(89aminoacids)andSDF-1beta(93aminoacids)arederivativesofanalternativesplicingevent.SDF-1αandSDF-1βhaveidenticalaminoacidsequences,differingonly,bythepresenceoffourextraaminoacidsattheC-terminusoftheβform.SDF-1betaisconstitutivelyexpressedbystromalcells.
GeneAliases:
Stromalcell-derivedfactor1,SDF-1,hSDF-1,C-X-Cmotifchemokine12,Intercrinereducedinhepatomas,IRH,Pre-Bcellgrowth-stimulatingfactor,PBSF.RecombinantHumanStromalCell-DerivedFactor-1Beta(CXCL12).
GenbankNumber:
P48061
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

