Overview:
A selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt31. It down-regulates cholesterol biosynthesis genes in primary striatal neurons1. Displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin2.
References:
1. DM Taylor et al. ACS Chem. Biol. 2011 6:5402. V Chopra et al. Cell Rep.2012 2:1492
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

