Overview:
BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 uM) as well as GLP HMTase (IC50 = 38 uM) leading to a decrease in H3K9Me2 (histone H3 lysine 9 methylation) in vitro1.It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming2.BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells3.It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells4.
References:
1. S Kubicek et al. Mol. Cell 2007 25:4732. D Huangfu et al. Nat. Biotechnol. 2008 26:7953. Y Shi et al. Cell Stem Cell2008 2:5254. Z Lu et al. Anticancer Drugs2013 24:484
ebiomall.com
>
>
>
>
>
>
>
>
>
>
>
>
那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

