Overview:
Selective Sirt1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or Sirt family members. Increases p53 acetylation following DNA damage1. Causes cell cycle arrest at G12.Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells3. An extremely useful tool for determining the involvement of Sirt1 in cellular physiology4. Cell permeable.
References:
1. JM Solomon et al. Mol. Cell. Biol. 200626:282. B Peck et al. Mol. Cancer Ther. 2010 9:8443. T Peled et al. Exp. Hematol.2012 40:3424. JL Andersen et al. Mol. Cell 2011 43:834
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那糖酵解中依赖NAD的酶不是要在线粒体内反应?
蛋白酶分布广泛,主要存在于人和动物消化道中,而消化道通过口与肛门与外界相通,属于外环境或外界环境
(溶菌酶、凝血酶原等)分布在内环境
(消化)酶分布在消化道

